Results 61 to 70 of about 21,006 (223)

Ursodeoxycholic acid treatment in cholesterol gallstone disease: effects on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, biliary lipid composition, and plasma lipid levels

Journal of Lipid Research, 1983
The present study was undertaken to characterize the effects of ursodeoxycholic acid on biliary lipid metabolism in man. Fifteen gallstone patients were treated with ursodeoxycholic acid at a daily dosage of 15 mg per kg body weight for about 4 weeks ...
B Angelin, S Ewerth, K Einarsson
doaj   +1 more source

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Adachi Y, Brendel C, Christian Zimmermann, Christoph Beglinger, Denk GU, Denson LA, Dietrich CG, Dietrich CG, Ee PL, Frank Lehmann, Freeman LA, Geier A, Gutmann H, Heike Gutmann, Hruz P, Imai Y, Janvilisri T, Jonker JW, Juergen Drewe, Jung D, Jung D, Kamisako T, Klucken J, Li N, Lown KS, Lu TT, Luigi Terracciano, Maliepaard M, Miyake K, Petr Hruz, Plebani M, Popowski K, Schellens JH, Smith M, Stedman CA, Stellaard F, Suzuki M, Taipalensuu J, Tanaka Y, Tanaka Y, Trauner M, Ulrich Beuers, van Herwaarden AE, Volk EL, Wagner M, Xie W, Yu L, Zimmermann C, Zollner G   +48 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

7 beta-Dehydroxylation of ursodeoxycholic acid by whole cells and cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 12708.

Journal of Lipid Research, 1982
Whole cells and cell extracts of Eubacterium species V. P. I. 12708 7-dehydroxylated [3H]ursodeoxycholic acid or [14C]chenodeoxycholic forming lithocholic acid.
B A White, R J Fricke, P B Hylemon
doaj   +1 more source

Circular dichroism spectroscopic detection of ligand binding induced subdomain IB specific structural adjustment of human serum albumin [PDF]

, 2013
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein.
Beaven G. H., Bertucci C., Bertucci C., Bhattacharya A. A., Brock A., Buttar D., Carter D. C., Curry S., Curry S., Datta P., Dockal M., Farruggia B., Fehske K. J., Fehske K. J., Fehske K. J., Ferenc Zsila, Ghuman J., Ishida S., Koide M., Kragh-Hansen U., Krenzel E. S., Plager J. E., Ryan A. J., Ryan A. J., Sengupta A., Shi D., Simard J. R., Sjöholm I., Strickland E. H., Sudlow G., Sudlow G., Takikawa H., Wanwimolruk S., Zhu L., Zsila F., Zsila F., Zunszain P. A., Zunszain P. A.   +37 more
core   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Ruminal methane inhibition potential of various pure compounds in comparison with garlic oil as determined with a rumen simulation technique (Rusitec) [PDF]

, 2017
Ruminants represent an important source of methane (CH4) emissions; therefore, CH4 mitigation by diet supplementation is a major goal in the current ruminant research. The objective of the present study was to use a rumen simulation technique to evaluate
Amelchanka, Sergej L., Duval, Stéphane M., Kreuzer, Michael, Soliva, Carla R.   +3 more
core  

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Synthesis of new bile salt analogues, sodium 3 alpha, 7 alpha-dihydroxy-5 beta-cholane-24-sulfonate and sodium 3 alpha, 7 beta-dihydroxy-5 beta-cholane-24-sulfonate.

Journal of Lipid Research, 1990
This report describes the chemical synthesis of two new bile salt analogues, namely sodium 3 alpha,7 alpha-dihydroxy-5 beta-cholane-24-sulfonate and sodium 3 alpha,7 beta-dihydroxy-5 beta-cholane-24-sulfonate from chenodeoxycholic acid and ...
K Kihira, M Yoshii, A Okamoto, S Ikawa, H Ishii, T Hoshita   +5 more
doaj   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source