Results 61 to 70 of about 14,871 (183)

Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol.

Journal of Lipid Research, 1984
Diosgenin and beta-sitosterol (1% in diet) were administered to CRJ:CD-1 male mice for 15 days, in order to examine the changes in bile acid metabolism.
K Uchida, H Takase, Y Nomura, K Takeda, N Takeuchi, Y Ishikawa   +5 more
doaj   +1 more source

Machine Learning‐Assisted Optimization of Iodide Electrolytes for Efficient Indoor Dye‐Sensitized Solar Cells with Engineered Photoanodes

Small Science, Volume 6, Issue 6, June 2026.
We developed dye‐sensitized solar cells (DSSCs) featuring an innovative photoanode architecture and employed a design‐of‐experiments (DoE) integrated with machine learning (ML) approaches to optimize iodide/triiodide‐based electrolytes for indoor photovoltaics.
Valid Mwalukuku, Antonio R. Blanco, Cyril Aumaître, Yann Kervella, Said Hamad, Renaud Demadrille, Juan A. Anta   +6 more
wiley   +1 more source

A Single Amino Acid Substitution in CspA Increases Germination Sensitivity and Broadens Bile Salt Germinant Specificity in Clostridioides difficile Spores

Environmental Microbiology, Volume 28, Issue 6, June 2026.
In reservoir‐associated RT033 strains, we observe a natural rewiring of spore germination that lowers the activation threshold and broadens bile‐salt specificity, enabling germination at low germinant levels and in response to typically inhibitory bile‐salts common in animal hosts.
Isabel Roseiro, Alexandra Nunes, Diogo Martins, Frederico Alves, Søren Persson, Adriano O. Henriques, Mónica Oleastro, Mónica Serrano   +7 more
wiley   +1 more source

Effect of chenodeoxycholic acid on biliary and urinary bile acids and bile alcohols in cerebrotendinous xanthomatosis; monitoring by high performance liquid chromatography.

Journal of Lipid Research, 1985
Biliary and urinary bile alcohol and bile acid composition has been determined by high performance liquid chromatography in patients with cerebrotendinous xanthomatosis before and after treatment with chenodeoxycholic acid.
A K Batta, S Shefer, M Batta, G Salen
doaj   +1 more source

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 12, Page 1658-1672, June 2026.
Serum conjugated primary bile acids accumulate in alcohol‐related hepatitis due to downregulation of hepatocyte bile acid transporters. Hepatocyte growth factor is elevated in alcohol‐related hepatitis and downregulates BSEP expression. This detrimentally affects the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis ...
Luke D. Tyson, Stephen Atkinson, Benjamin H. Mullish, Alexandros Pechlivanis, Michael Allison, Andrew Austin, Katie Chappell, Stuart J. Forbes, Ewan H. Forrest, Alastair M. Kilpatrick, Tong Liu, Laura Martinez‐Gili, Steven Masson, Mark J. W. McPhail, Joao Nunes, Paul Richardson, Daniel Rodrigo‐Torres, Stephen D. Ryder, Mark Wright, Vishal C. Patel, Nikhil Vergis, Elaine Holmes, Mark R. Thursz   +22 more
wiley   +1 more source

Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models

Nature Communications
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening mucocutaneous adverse drug reactions characterized by disseminated skin and mucosal detachment.
Haruna Kimura, Akito Hasegawa, Tomoki Nishiguchi, Hong Ha Nguyen, Masatoshi Eguchi, Manao Kinoshita, Youichi Ogawa, Takeaki Ozawa, Riichiro Abe   +8 more
doaj   +1 more source

Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids.

Journal of Lipid Research, 1995
Bile acid biosynthesis has been believed to be regulated by negative feedback control; however, recent experiments have cast considerable doubts on the concept. The aim of the study was to examine the consensus of the negative feedback regulation of bile
K Fukushima, H Ichimiya, H Higashijima, H Yamashita, S Kuroki, K Chijiiwa, M Tanaka   +6 more
doaj   +1 more source

Quantitative aspects of the interaction of bile acids with human serum albumin.

Journal of Lipid Research, 1982
The interaction of human serum albumin with twelve bile acids (ba) has been studied by equilibrium dialysis technique using 3H- and 14C-labeled bile acids.
A Roda, G Cappelleri, R Aldini, E Roda, L Barbara   +4 more
doaj   +1 more source

Biotransformation of chenodeoxycholic acid by Pseudomonas species NCIB 10590 under anaerobic conditions.

Journal of Lipid Research, 1983
The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified.
R W Owen, M J Hill, R F Bilton
doaj   +1 more source

Measurement of sulfated and nonsulfated bile acids in human serum and urine

Journal of Lipid Research, 1974
Amberlite XAD-2 was used to extract bile acids from urine or diluted serum of patients with hepatobiliary diseases. Columns containing Sephadex LH-20 were then used to separate the sulfated and nonsulfated bile acids.
Isao Makino, Kenjiro Shinozaki, Shoichi Nakagawa, Keimei Mashimo   +3 more
doaj   +1 more source