Results 101 to 110 of about 5,134,427 (306)

The ionization behavior of bile acids in different aqueous environments.

Journal of Lipid Research, 1987
The ionization behavior of cholic acid, deoxycholic acid, and chenodeoxycholic acid in a variety of physiologically important molecular environments was studied using 13C NMR spectroscopy.
D J Cabral, J A Hamilton, D M Small
doaj   +1 more source

Advances in the Gut‐Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential

Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.
ABSTRACT Background Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advancements in the “gut‐lung” axis concept have elucidated the intricate immunometabolic crosstalk between the gastrointestinal tract
Ting Zheng, Yi Huang, Hongmei Yao
wiley   +1 more source

Biliary bile acids of fruit pigeons and doves (Columbiformes): presence of 1-beta-hydroxychenodeoxycholic acid and conjugation with glycine as well as taurine.

Journal of Lipid Research, 1994
The biliary bile acid composition of 30 species of pigeons and doves belonging to seven genera in the avian order Columbiformes was determined using TLC, HPLC, GLC/MS, LSIMS, and NMR.
L.R Hagey, C.D Schteingart, H T Ton-Nu, A.F Hofmann   +3 more
doaj   +1 more source

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]

, 2019
Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric, Cheung, Kit Wun Kathy, Chien, Huan-Chieh, Feofanova, Elena V, Giacomini, Kathleen M, Irannejad, Roshanak, Kinchen, Jason M, Stecula, Adrian, Suhre, Karsten, van Borselen, Marjolein, Yee, Sook Wah, Yousri, Noha A, Yu, Bing, Zou, Ling   +13 more
core   +2 more sources

Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate (GCDCA‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1532-1542, December 2025.
Endogenous biomarkers for drug transporters are an emerging tool for the assessment of transporter‐mediated drug–drug interactions (DDI). Glycochenodeoxycholic acid 3‐O‐sulfate (GCDCA‐S) has been proposed as a Tier 2 biomarker of hepatic OATP1B3 and renal OAT3 transporters by the International Transporter Consortium.
Yuki Ujihira, Viktor Georgiev, Kayode Ogungbenro, Aleksandra Galetin   +3 more
wiley   +1 more source

27-Hydroxycholesterol: production rates in normal human subjects

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol.

Journal of Lipid Research, 1984
Diosgenin and beta-sitosterol (1% in diet) were administered to CRJ:CD-1 male mice for 15 days, in order to examine the changes in bile acid metabolism.
K Uchida, H Takase, Y Nomura, K Takeda, N Takeuchi, Y Ishikawa   +5 more
doaj   +1 more source

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma [PDF]

, 2019
Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis.
Adorini, L., Alvaro, D., Berloco, P. B., Bragazzi, M., Cardinale, V., Carpino, G., Costantini, D., De Rose, A. M., Di Matteo, S., Gaudio, E., Giorgi, A., Giuliante, F., Giulitti, F., Grazi, G., Manzi, E., Melandro, F., Napoletano, C., Nevi, L., Overi, D., Safarikia, S.   +19 more
core   +3 more sources

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload [PDF]

, 2011
Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed.
Alan Waring, Bo Qiao, Elizabeta Nemeth, Emilio Ramos, Fujita, Gloria C. Preza, Gualdi, Kearney, Lyskov, Michael A. Peralta, Nemeth, Piotr Ruchala, Porter, Rogelio Pinon, Sham, Shantanu Sharma, Tomas Ganz   +16 more
core   +2 more sources

Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids.

Journal of Lipid Research, 1995
Bile acid biosynthesis has been believed to be regulated by negative feedback control; however, recent experiments have cast considerable doubts on the concept. The aim of the study was to examine the consensus of the negative feedback regulation of bile
K Fukushima, H Ichimiya, H Higashijima, H Yamashita, S Kuroki, K Chijiiwa, M Tanaka   +6 more
doaj   +1 more source