Results 21 to 30 of about 20,520 (283)

Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells [PDF]

, 2009
In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower
Alan F. Hofmann, Barcelo, Barrett, Bertelsen, Cartwright, Chadwick, Cheng, Cheng, Christine Marsh, Dawson, Dawson, Devor, Dharmsathaphorn, Fernandez-Banares, Gail Ferguson, Gelbmann, Gordon, Hamilton, Hofmann, J-P, Kalia, Keely, Keely, Keely, Khurana, Kok, Kruis, Magdalena S. Mroz, Mauricio, Mekjian, Merchant, Michael M. Scharl, Milovic, Montrose, Muhlbauer, Münch, Niamh Keating, Nyhlin, Potter, Raimondi, Smith, Stephen J. Keely, Teem, Ung, Venkatasubramanian, Weihrauch   +45 more
core   +1 more source

Treatment of Constipation with Chenodeoxycholic Acid

Journal of International Medical Research, 1983
The aim of this study was to investigate whether the cathartic effect of chenodeoxycholic acid (CDCA) could be helpful in the management of chronic constipation. Twenty cholesterol gall-stone patients with chronic constipation were randomly treated with either CDCA (750 mg/day in three divided doses at meals) or placebo for a period of 4 weeks.
E Roda, A Petronelli, F Bazzoli, Barbara L, M. Malavolti   +4 more
openaire   +3 more sources

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]

, 1992
As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Adamczyk W, Andrén-Sandberg A, Aronchick CA, Björnsson OG, Björnsson OG, Brand SJ, Burhol PG, Davies HA, Dragstedt LR, Erlinger S, Eyre-Brook IA, Fausa O, Fiedler F, Forell MM, Forell MM, Forell MM, Forell MM, Forell MM, Frühauf S, Fölsch UR, Geratz JD, Gomez G, Green GM, Gries E, Grundy SM, Hanssen LE, Hartmann W, Hellmann G, Holtermuller KH, Holtermuller KH, Hotz J, Ivy AC, Kataoka K, Konturek SJ, Koop I, Koop I, Koop I, Koop I, Koop I, Kurosawa H, Kuroyanagi Y, Lagerlöf HO, Lehnert P, Lueth HC, Malagelada J-R, Malagelada J-R, Malagelada J-R, Mellanby J, Meyer JH, Miyasaka K, Miyasaka K, Miyasaka K, Miyasaka K, Nakamura R, Nakamura R, Namba M, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, Osnes M, Otte M, Peter Lehnert, Riepl RL, Riepl RL, Riepl RL, Riepl RL, Rudolf L. Riepl, Schaffalitzky de Muckadell OB, Shiratori K, Smallwood RA, Staub VL, Thomas JE, van Levan H, Wormsley KG   +75 more
core   +1 more source

Improved performance of porphyrin-based dye sensitised solar cells by phosphinic acid surface treatment [PDF]

, 2009
Chemical surface treatment of porphyrin-sensitised titania films using bis-(4-methoxyphenyl) phosphinic acid after dye adsorption, results in large improvements in DSSC efficiencies which originate primarily from higher short circuit currents. The result
Alessandra Allegrucci, Attila J. Mozer, Campbell, David L. Officer, Durrant, Fabregat-Santiago, Forneli, Frank, Guerrero, Haque, Haque, Kanzaki, Katoh, Kenji Sunahara, Koumura, Kuang, Kuciauskas, Lee, Leone Spiccia, Lynn Dennany, Miyashita, Mozer, Nakade, Nakade, Naomi A. Lewcenko, Neale, O'Regan, Paulsson, Pawel Wagner, Shogo Mori, Wang, Wang, Wang, Wang, Watson, Yum   +35 more
core   +2 more sources

Symmetry Scheme for Amino Acid Codons [PDF]

Phys.Rev.E65, 021912 (2002), 2003
Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv   +1 more source

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans [PDF]

, 2016
Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate.
Botham, Buffie, C. Roland Wolf, Cen Xie, Chad N. Brocker, Cheng, Cheung, Colin J. Henderson, de Aguiar Vallim, Deo, Dragin, Fedorowski, Frank J. Gonzalez, Gonzalez, Greathouse, Gu, Hardison, Hasegawa, Hirano, Hofmann, Hofmann, Inagaki, Jiang, Jiang, Jones, Katagiri, Kristopher W. Krausz, Li, Löfgren, Matsubara, Mueller, Nelson, Russell, Russell, Sayin, Scheer, Scheer, Scheer, Scheer, Seeley, Shogo Takahashi, Tanaka, Tatsuki Fukami, Thomas, van Herwaarden, Yusuke Masuo   +45 more
core   +2 more sources

Evaluating hepatobiliary transport with 18F-labeled bile acids : the effect of radiolabel position and bile acid structure on radiosynthesis and in vitro and in vivo performance [PDF]

, 2018
Introduction. An in vivo determination of bile acid hepatobiliary transport efficiency can be of use in liver disease and preclinical drug development.
De Lombaerde, Stef, De Vos, Filip, Kersemans, Ken, Neyt, Sara, Vanhove, Christian, Verhoeven, Jeroen   +5 more
core   +3 more sources

Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]

arXiv, 2023
Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv  

Learning the Hydrophilic, Hydrophobic and Aromatic Character of Amino Acids from their Interfacial Thermal Conductance in Water [PDF]

, 2021
In this study, the thermal relaxation of the 20 naturally occurring amino-acids in water is investigated using transient non-equilibrium molecular-dynamics simulations. By modeling the thermal relaxation process, the relaxation times of the amino-acids in water occurs over a timescale covering 2-5 ps.
arxiv   +1 more source

Chenodeoxycholic acid therapy for hypertriglyceridaemia in men. [PDF]

British Journal of Clinical Pharmacology, 1978
1 Ten consecutive patients with hypertriglyceridaemia who adhered to a low carbohydrate diet without complete control of serum triglycerides were started on chenodeoxycholic acid 750 mg daily and followed monthly for 6 months. Nine of these patients were then followed for a further month on placebo capsules and thereafter monthly for a further 6 months
Ian A.D. Bouchier, Bateson Mc, JR Evans, D Maclean   +3 more
openaire   +3 more sources