Results 51 to 60 of about 20,520 (283)

Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry [PDF]

, 2010
Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification.
Alnouti, Ando, Arnold von Eckardstein, Bentayeb, Bjorkhem, Burkard, Camilleri, Carine Steiner, Cariou, Caron, Claudel, DeBarber, Duran-Sandoval, Honda, Karuna, Katharina M. Rentsch, Kuipers, Lefebvre, Lovgren-Sandblom, Makishima, Parks, Sauter, Scherer, Staels, Tagliacozzi, Tessier, Wang, Xiang, Ye, Zhang   +29 more
core   +1 more source

Never Late: Cerebrotendinous Xanthomatosis and Improvements in Neurocognitive Functions in an Adult Patient on Chenodeoxycholic Acid Treatment

Clinical Genetics, EarlyView.
Cerebrotendinous xanthomatosis is due to biallelic pathogenic variants in CYP27A1. We report a new patient and his good neurocognitive outcome on the chenodeoxycholic acid treatment despite therapy starting at the age of 34 years. This highlights the importance of recognizing treatable inherited metabolic diseases at any age.
Randa Sultan, Marta Villa‐Lopez, Clara Hung, Morganne McCabe, Oksana Suchowersky, Jordan Urlacher, Saadet Mercimek‐Andrews   +6 more
wiley   +1 more source

Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients [PDF]

, 2016
Aims: Treatment with glucagon-like peptide (GLP)-1 receptor agonists or dipeptidyl peptidase (DPP)-4 inhibitors might increase gallstone formation; however, the mechanisms involved are unknown. We aimed to assess the effects of these drugs on gallbladder
Cahen, D.L. (Djuna), Diamant, M. (Michaela), Groen, A. (Albert), Hoekstra, T. (Trynke), Kramer, M.H.H. (Mark), Muskiet, M.H.A. (Marcel H. A.), Nieuwdorp, M. (Max), Smits, M.M. (Mark M.), Tonneijck, L. (Lennart), van Raalte, D.H. (Daniël H.)   +9 more
core   +1 more source

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Carbon Doping of MgB2 by Toluene and Malic-Acid-in-Toluene [PDF]

, 2010
The decomposition of malic acid in the presence of Mg and B was studied using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) which revealed that malic acid reacted with Mg but not B. Also, the addition of toluene to dissolve malic acid followed by subsequent drying resulted in no reaction with Mg, indicating that the malic
arxiv   +1 more source

Large presence of carbonic acid in CO$_2$-rich aqueous fluids under Earth's mantle conditions [PDF]

Journal of Physical Chemistry Letters 10, 5135-5141 (2019), 2019
The chemistry of carbon in aqueous fluids at extreme pressure and temperature conditions is of great importance to Earth's deep carbon cycle, which substantially affects the carbon budget at Earth's surface and global climate change. At ambient conditions, the concentration of carbonic acid in water is negligible, so aqueous carbonic acid was simply ...
arxiv   +1 more source

Suitability of [11,12-3H2]chenodeoxycholic acid and [11,12-3H2]lithocholic acid for isotope dilution studies of bile acid metabolism in man

Journal of Lipid Research, 1977
Studies were carried out to assess the stability of the label in [11,12-3H2]chenodeoxycholic acid and [11,12-3H2]lithocholic acid during enterohepatic cycling and thus define the suitability of these tracers for isotope dilution studies of bile acids in ...
P Y Ng, R N Allan, A F Hofmann
doaj  

Ruminococcus gnavus in the gut: driver, contributor, or innocent bystander in steatotic liver disease?

The FEBS Journal, Volume 292, Issue 6, Page 1252-1264, March 2025.
Ruminococcus gnavus (R. gnavus) can degrade mucin, modify bile acids, and secrete metabolites into circulation via the portal vein to the liver for further processing and subsequent systemic circulation. R. gnavus is associated with metabolic syndrome and inflammatory bowel disease severity. It is suspected that R.
Vik Meadows, Jayson M. Antonio, Ronaldo P. Ferraris, Nan Gao   +3 more
wiley   +1 more source

A search for mid-IR bands of amino acids in the Perseus Molecular Cloud [PDF]

arXiv, 2021
Amino acids are building-blocks of proteins, basic constituents of all organisms and essential to life on Earth. They are present in carbonaceous chondrite meteorites and comets, but their origin is still unknown. Formation of amino acids in the interstellar medium is posible via specific gas-phase reactions in dark clouds, however sensitive ...
arxiv  

Identification of novel bile acids as biomarkers for the early diagnosis of Niemann-Pick C disease [PDF]

, 2016
This article describes a rapid UPLC-MS/MS method to quantitate novel bile acids in biological fluids and the evaluation of their diagnostic potential in Niemann-Pick C (NPC). Two new compounds, NPCBA1 (3β-hydroxy,7β-N-acetylglucosaminyl-5-cholenoic acid)
Camuzeaux, S, Clayton, PT, Gissen, P, Iida, T, Maekawa, M, Mano, N, Mazzacuva, F, Mills, K, Mills, P, Nicoli, E-R, Platt, F, Porter, FD, te Vruchte, D, Wassif, C   +13 more
core   +1 more source