Optimum level of NEDD4 and its interaction with nsP3 are crucial to facilitate efficient Chikungunya virus (CHIKV) infection. [PDF]
Chikungunya is a febrile infection caused by the Chikungunya virus (CHIKV), an alphavirus which has emerged as a serious public health problem globally. Despite extensive research, our understanding of different host factors facilitating effective CHIKV infection is not clear yet. NEDD4, a member of the E3 ubiquitin ligase, is one such protein.
Verma S +7 more
europepmc +3 more sources
Analysis of Humoral Immune Responses in Chikungunya Virus (CHIKV)-Infected Patients and Individuals Vaccinated with a Candidate CHIKV Vaccine [PDF]
Abstract Background Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe flu-like symptoms. The acute symptoms disappear after 1 week, but chronic arthralgia can persist for years.
Lisa Henß +7 more
openalex +5 more sources
AbstractConcomitant circulation of dengue and chikungunya viruses has been sporadically reported and needs to be individually diagnosed. Several sensitive molecular diagnostics are currently deployed for the diagnosis of both DENV and CHIKV, it is very difficult to delineate the two viral infections based on symptomology, as both share similar clinical
Rohit Sagar +9 more
openalex +3 more sources
In silico analysis of Chikungunya virus (CHIKV), a mosquito-borne alphavirus
Chikungunya virus (CHIKV) is a mosquito-borne alpha virus, which belongs to the family, Togaviridae. This virus is known to cause an acute onset of high fever, severe arthralgia and rash, and is usually accompanied by headache and severe joint pain.
Hassuzana Khalil +2 more
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Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate [PDF]
Our previous investigation of the nucleolar localisation sequence (NoLS) of chikungunya virus (CHIKV) capsid protein demonstrated the role of capsid in CHIKV virulence. Mutating the NoLS of capsid in CHIKV led to the development of a unique live-attenuated CHIKV vaccine candidate, termed CHIKV-NoLS.
Eranga Abeyratne +4 more
openalex +6 more sources
Treatment of Chikungunya Virus (CHIKV) Using Targeted Immunotherapy
Chikungunya virus (CHIKV) is the most common mosquito-borne Alphavirus infecting humans worldwide. Up to date, there are no antiviral treatments or vaccines approved to treat or prevent CHIKV for which treatments remain symptomatic based on clinical manifestations.
Fleury Augustin Nsole Biteghe +5 more
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Chikungunya virus (CHIKV) infection: Analytical performance of real-time NASBA assay [PDF]
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Giada Rossini +5 more
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Objective: The present study aims to outline the genotype of circulating CHIKV strains in Pakistan and their phylogenetic analysis Methods: The study is being conducted at Armed Forces Institute of Pathology after the approval by Institutional Review Board. The study was conducted during the period of Aug 2016 to Sep 2017.
Humaira Aziz Sawal +3 more
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EPH15 Transmission Dynamics and Vaccination Strategies for Chikungunya Virus (CHIKV): An Outbreak Simulation Study in Rome, Italy [PDF]
Giorgia Tiozzo +4 more
openalex +2 more sources
Chikungunya virus (CHIKV) outbreak in Feira de Santana, Bahia: preliminary report [PDF]
Karen Soares Trinta +7 more
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