Results 61 to 70 of about 15,418 (233)

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

Antiviral Research, 2014
The global emergence of Chikungunya virus (CHIKV) infection is alarming and currently there is no licensed vaccine or antiviral treatment available to mitigate this disease. CHIKV infection typically results in high viral load with an outcome of high fever, skin rashes, muscle pain, and sequelae of prolonged arthritis, which occurs in >90% of the ...
Abhay P. S. Rathore, Timothy Haystead, Pratyush Kumar Das, Andres Merits, Mah Lee Ng, Subhash G. Vasudevan   +5 more
openalex   +4 more sources

Nonstructural Protein 2 (nsP2) of Chikungunya Virus (CHIKV) Enhances Protective Immunity Mediated by a CHIKV Envelope Protein Expressing DNA Vaccine [PDF]

Viral Immunology, 2013
Chikungunya virus (CHIKV) is an important emerging mosquito-borne alphavirus, indigenous to tropical Africa and Asia. It can cause epidemic fever and acute illness characterized by fever and arthralgias. The epidemic cycle of this infection is similar to dengue and urban yellow fever viral infections.
Huihui Bao, Aarti Ramanathan, Omkar Kawalakar, Senthil G. Sundaram, Colleen Tingey, Charoran B. Bian, Nagarajan Muruganandam, Paluru Vijayachari, Niranjan Y. Sardesai, David B. Weiner, Kenneth E. Ugen, Kar Muthumani   +11 more
openalex   +5 more sources

Nanotechnology: A promising approach of antiviral treatments against chikungunya virus (CHIKV)

Journal of Scientific and Innovative Research, 2018
Following its emergence in Africa, spread to the Indian Ocean islands in 2006, and occurrences in regions of the world where it hadn’t been reported in the past, Chikungunya has become an emerging public health concern in many countries. The past outbreaks of the chikungunya virus (CHIKV) have caused widespread morbidity and mortality.
Rishikesh Kumar, Ganesh Chandra Sahoo, Bhawna Verma, Aparna Ramachandran, Mohammad Yousuf Ansari, Krishna Pandey, VNR Das, RK Topno, Major Madhukar, Pradeep Das   +9 more
openalex   +2 more sources

Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus

Viruses, 2019
Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia.
César López-Camacho, Young Chan Kim, Joshua Blight, Marcos Lazaro Moreli, Eduardo Montoya-Diaz, Juha T Huiskonen, Beate Mareike Kümmerer, Arturo Reyes-Sandoval   +7 more
doaj   +1 more source

High prevalence of arthralgia among infants with Chikungunya disease during the 2019 outbreak in northern region of the state of Rio de Janeiro

Frontiers in Pediatrics, 2022
IntroductionIn a low-income setting with simultaneous presence of Dengue virus, Zika virus, and Chikungunya virus (CHIKV) in the same region, the difficulty of establishing a clinical diagnosis when the molecular test is not a possibility.
Patrícia Damião Gomes, Rayane Figueiredo Silva Moreira Carvalho, Milena Moulin Massini, Rafael Hauaji Garzon, Pollianny Louzada Schiavo, Regina Célia de Souza Campos Fernandes, Regina Célia de Souza Campos Fernandes, Thaís Louvain de Souza   +7 more
doaj   +1 more source

Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]

, 2014
Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle, Kohl, Alain, Rainey, Stephanie M., Shah, Pranav   +3 more
core   +1 more source

Vaccine-induced skewing of T cell responses protects against Chikungunya virus disease [PDF]

, 2019
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T ...
Ando, Takeshi, Broeckel, Rebecca M, Curiel, David T, DeFilippis, Victor, Denton, Michael, Dmitriev, Igor, Haese, Nicole, Heise, Mark, Kreklywich, Craig N, Messaoudi, Ilhem, Morrison, Thomas E, Powers, John, Smith, Patricia, Streblow, Daniel N   +13 more
core   +3 more sources

Dengue-chikungunya infection in the tertiary care hospital of northern India: Cross-sectional latent class cluster analysis in viral infection

Heliyon, 2023
Cases of dengue and chikungunya fever are escalating all over India. Both viruses share a common vector, the “Aedes” mosquito. Due to similar clinical symptoms, both the dengue (DENV) and chikungunya (CHIKV) virus can circulate as co-infection.
Gaurav Badoni, Puneet Kumar Gupta, Pratima Gupta, Neelam Kaistha, Yogendra Pratap Mathuria, Manju O. Pai, Ravi Kant   +6 more
doaj   +1 more source

Mutations in the E2 glycoprotein and the 3\u27 untranslated region enhance chikungunya virus virulence in mice [PDF]

, 2017
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection.
Carpentier, Kathryn S, Diamond, Michael S, Fox, Julie M, Hawman, David W, May, Nicholas A, Montgomery, Stephanie A, Moorman, Nathaniel J, Morrison, Thomas E, Sanders, Wes   +8 more
core   +3 more sources

Unbiased Metagenomic Sequencing for Pediatric Meningitis in Bangladesh Reveals Neuroinvasive Chikungunya Virus Outbreak and Other Unrealized Pathogens. [PDF]

, 2019
The burden of meningitis in low-and-middle-income countries remains significant, but the infectious causes remain largely unknown, impeding institution of evidence-based treatment and prevention decisions.
Crawford, Emily D., de Bourcy, Charles, De Carvalho, Tiago Rodrigues, DeRisi, Joseph L., Dimitrov, Boris, Duggal, Nisha, Egger, Rebecca, Hasanuzzaman, Md, Islam, Maksuda, Juan, Yun-Fang, Kalantar, Katrina, Khan, Lillian M., Langelier, Charles, Li, Lucy M., Malaker, Roly, Mayday, Madeline Y., Rahman, Hafizur, Ramesh, Akshaya, Saha, Samir K., Saha, Senjuti, Sajib, M. S. I., Sheu, Jonathan, Tang, Jennifer, Tato, Cristina M., Wang, James, Wilson, Michael R.   +25 more
core   +2 more sources