Results 81 to 90 of about 19,855 (219)

Development of a next-generation chikungunya virus vaccine based on the HydroVax platform

PLoS Pathogens, 2022
Chikungunya virus (CHIKV) is an emerging/re-emerging mosquito-borne pathogen responsible for explosive epidemics of febrile illness characterized by debilitating polyarthralgia and the risk of lethal infection among the most severe cases.
Dawn K Slifka, H. Raué, W. Weber, Takeshi Andoh, C. Kreklywich, Victor R. Defilippis, D. Streblow, M. Slifka, Ian J. Amanna   +8 more
semanticscholar   +1 more source

Why Can We See a Local Spread of Chikungunya Virus (CHIKV) Infection?

International Journal of Travel Medicine and Global Health, 2014
Neha Alang
openalex   +2 more sources

A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus

Nature Medicine, 2021
Chikungunya virus (CHIKV) infection causes acute disease characterized by fever, rash and arthralgia, which progresses to severe and chronic arthritis in up to 50% of patients.
A. August, H. Attarwala, Sunny Himansu, S. Kalidindi, Sophia Lu, R. Pajon, Shu Han, J. Lecerf, J. Tomassini, M. Hard, L. Ptaszek, J. Crowe, T. Zaks   +12 more
semanticscholar   +1 more source

Development of a Novel Aedes aegypti Repellent: An Integrated Approach Combining In Silico and Bioassays

Chemistry &Biodiversity, EarlyView.
OBP1 plays an essential role in the behavior response of Aedes aegypti. The computational approaches employed herein suggest a compound with repellency activity in the ZINC database, which was confirmed by bioassays. ABSTRACT Aedes aegypti is the most important vector of arboviruses, which are responsible for 3.9 billion cases worldwide.
Moysés Fagundes de Araujo Neto, Jânio Rodrigo de Jesus Santos, Ana Luiza Pontes Silva de Oliveira, Antonio Wanderson Vieira Gois, Ingrid Bernardes Santana Martins, Vitor Barbanti Pereira Leite, Adriano Figueiredo Monte Alegre, Jairo Torres Magalhães Junior, Franco Henrique Andrade Leite   +8 more
wiley   +1 more source

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, EarlyView.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

HLA class I restriction as a possible driving force for Chikungunya evolution.

PLoS ONE, 2010
After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) was reported in Africa, several islands in the Indian Ocean, South-East Asia and the Pacific causing unprecedented morbidity with some cases of fatality. Early phylogenetic
Joo Chuan Tong, Diane Simarmata, Raymond T P Lin, Laurent Rénia, Lisa F P Ng   +4 more
doaj   +1 more source

Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.

Cell Host and Microbe, 2021
Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and transcription by anchoring the viral replication complex (RC) to plasma membrane ...
Kuo Zhang, Y. Law, M. Law, Yaw Bia Tan, M. Wirawan, D. Luo   +5 more
semanticscholar   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, EarlyView.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source

Antivirals against the Chikungunya Virus

Viruses, 2021
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in recent decades, causing large-scale epidemics in many parts of the world.
Verena Battisti, E. Urban, T. Langer
semanticscholar   +1 more source

Nicotiana benthamiana as a Source of Cowpea Mosaic Virus‐Derived Particles That Specifically Package Designer RNAs

Plant Biotechnology Journal, EarlyView.
ABSTRACT The coupling of replication and encapsidation in the bipartite plant virus, cowpea mosaic virus (CPMV), has been used to specifically incorporate designer RNA molecules into viral particles via transient expression in Nicotiana benthamiana. This is achieved by placing the desired RNA sequence between the 5′ and 3′ UTRs of CPMV RNA‐2 so that ...
H. Peyret, S. N. Shah, Y. Meshcheriakova, J.‐W. Jung, K. Saunders, G. P. Lomonossoff   +5 more
wiley   +1 more source