Results 61 to 70 of about 14,798 (236)

Transmission dynamics of the ongoing chikungunya outbreak in Central Italy. From coastal areas to the metropolitan city of Rome, summer 2017 [PDF]

, 2017
A large chikungunya outbreak is ongoing in Italy, with a main cluster in the Anzio coastal municipality. With preliminary epidemiological data, and a transmission model using mosquito abundance and biting rates, we estimated the basic reproduction number
Caputo, Beniamino, DELLA TORRE, Alessandra, Filipponi, Federico, Guzzetta, Giorgio, Manica, Mattia, Merler, Stefano, Poletti, Piero, Rosà, Roberto, Solimini, ANGELO GIUSEPPE   +8 more
core   +2 more sources

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants.

PLoS Pathogens, 2011
Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics throughout Africa and Asia, causing infectious arthritis and reportedly linked with fatal infections in newborns and elderly.
Chia Yin Lee, Yiu-Wing Kam, Jan Fric, Benoit Malleret, Esther G L Koh, Celine Prakash, Wen Huang, Wendy W L Lee, Cui Lin, Raymond T P Lin, Laurent Renia, Cheng-I Wang, Lisa F P Ng, Lucile Warter   +13 more
doaj   +1 more source

The transient expression of CHIKV VLP in large stirred tank bioreactors

Cytotechnology, 2019
Transient gene expression (TGE) bioprocesses have been difficult to scale up in large stirred tank bioreactors with volumes of more than 1.5 L. Low production levels are often observed, but the causes have not been investigated (Gutierrez-Granados et al. in Crit Rev Biotechnol 38:918-940, 2018).
Peifeng Chen, Jacob Demirji, Vera B. Ivleva, Joe Horwitz, Richard Schwartz, Frank Arnold   +5 more
openalex   +5 more sources

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources

Chikungunya virus populations experience diversity- dependent attenuation and purifying intra-vector selection in Californian Aedes aegypti mosquitoes.

PLoS Neglected Tropical Diseases, 2019
Chikungunya virus (Togaviridae, Alphavirus; CHIKV) is a mosquito-borne global health threat that has been transmitted transiently in the southeastern United States.
Kasen K Riemersma, Lark L Coffey
doaj   +1 more source

Ten years since the last Chikungunya virus outbreak in Italy. History repeats itself [PDF]

, 2017
The prevalence of Arbovirus (arthropod-borne virus) infections is increasing worldwide. Recently, new clusters of autochthonous cases have been reported in countries with temperate climates where the competent vector is present.
Franchini, Massimo, Liumbruno, Giancarlo M., Marano, Giuseppe, Masiello, Francesca, Pati, Ilaria, Pupella, Simonetta, Vaglio, Stefania, Velati, Claudio   +7 more
core   +1 more source

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, Volume 7, Issue 2, February 2026.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

Chikungunya virus-induced autophagy delays caspase-dependent cell death [PDF]

, 2012
Autophagy is an important survival pathway and can participate in the host response to infection. Studying Chikungunya virus (CHIKV), the causative agent of a major epidemic in India, Southeast Asia, and southern Europe, we reveal a novel mechanism by ...
Alessandra Giodini, Alexander, Alexander, Beth Levine, Blanchet, Bodenmann, Borgherini, Cadwell, Cadwell, Cataldi, Claire de la Calle, Couderc, Crotzer, Danial, de la Calle, Deborah J. Lenschow, Dengjel, Deretic, Djavaheri-Mergny, Djavaheri-Mergny, Dreux, English, Enserink, Everett, Filomeni, Florence Guivel-Benhassine, Gannagé, Griffin, Guo, Gérardin, He, Inoue, Jan, Joubert, Joubert, Jounai, Kang, Kepp, Krakauer, Krejbich-Trotot, Krejbich-Trotot, Kroemer, Kroemer, Kurokawa, Kurokawa, Lee, Lee, Li, Li, Liang, Lucie Peduto, Manimunda, Mason, Matthew L. Albert, McGuckin, Mehrpour, Nakagawa, Ng, Novo, Olivier Schwartz, Orvedahl, Orvedahl, Orvedahl, Ozden, Pierre-Emmanuel Joubert, Powers, Schilte, Schuffenecker, Schwartz, Scott W. Werneke, Simon, Sourisseau, Teodoro, Thomson, Thorburn, Uhl, Urano, Vanlandingham, Watson, Wei, Wilson, Yatim, Yoshida, Zhang, Zoncu   +84 more
core   +2 more sources