Results 211 to 220 of about 311,648 (345)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Enhanced Immunogenicity and Affinity with A35R-Fc-Based Chimeric Protein Compared to MPXV A35R Protein. [PDF]

Viruses
Bai S, Cui Y, Liao Q, Yi H, Liao Z, Zhang G, Wu F, Lu H.   +7 more
europepmc   +1 more source

In silico analyses and design of a chimeric protein containing epitopes of SpaC, PknG, NanH, and SodC proteins for the control of caseous lymphadenitis. [PDF]

Appl Microbiol Biotechnol, 2021
Silva MTO, de Pinho RB, Bezerra FSB, Scholl NR, Moron LD, Alves MSD, Woloski RDS, Kremer FS, Borsuk S.   +8 more
europepmc   +1 more source

Design of chimeric (metallo-) proteins for the development of novel bio-inspired materials

, 2016
Alexandra Louka
openalex   +1 more source

Recovery and Altered Neutralization Specificities of Chimeric Viruses Containing Capsid Protein Domain Exchanges from Antigenically Distinct Strains of Feline Calicivirus

, 2000
John D. Neill, Stanislav V. Sosnovtsev, Kim Y. Green   +2 more
openalex   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

A highly efficient soybean transformation system using GRF3-GIF1 chimeric protein. [PDF]

J Integr Plant Biol
Zhao Y, Cheng P, Liu Y, Liu C, Hu Z, Xin D, Wu X, Yang M, Chen Q.   +8 more
europepmc   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Design and computational analysis of a novel Azurin-BR2 chimeric protein against breast cancer. [PDF]

Toxicol Res (Camb)
Rehman HM, Yousaf N, Hina SM, Nadeem T, Ansari MA, Chaudry A, Kafait I, Khalid S, Alanzi AR, Bashir H.   +9 more
europepmc   +1 more source

Flowering Locus T chimeric protein induces floral precocity in edible citrus. [PDF]

Plant Biotechnol J, 2021
Sinn JP, Held JB, Vosburg C, Klee SM, Orbovic V, Taylor EL, Gottwald TR, Stover E, Moore GA, McNellis TW.   +9 more
europepmc   +1 more source