Results 231 to 240 of about 311,648 (345)

A Chimeric UDP-Glucose Pyrophosphorylase Produced by Protein Engineering Exhibits Sensitivity to Allosteric Regulators [PDF]

, 2013
Matías D. Asención Diez, Ana C. Ebrecht, Lucila Inés Martínez, Mabel Aleanzi, Sergio A. Guerrero, Miguel A. Ballícora, Alberto Á. Iglesias   +6 more
openalex   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Layered Double Hydroxides (LDH) as Delivery Vehicles of a Chimeric Protein Carrying Epitopes from the Porcine Reproductive and Respiratory Syndrome Virus. [PDF]

Pharmaceutics
Alonso-Cerda MJ, García-Soto MJ, Miranda-López A, Segura-Velázquez R, Sánchez-Betancourt JI, González-Ortega O, Rosales-Mendoza S.   +6 more
europepmc   +1 more source

Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus [PDF]

Shuai Shao, Xuefeng Zhang, Jun Hou, Sen Yang, Zi Bo Han, Hai Lan Wu, Fang Tang, Xin Yu Li, Ze Hua Lei, Zi Xin Zhao, Shu Xiang Li, Zhao Ming Liu, Pu Shan, Yu Jin, Ji Guo Su, Liang Yu, Jing Zhang, Qi Ming Li   +17 more
openalex   +1 more source

Serological responses to a soluble recombinant chimeric Plasmodium vivax circumsporozoite protein in VK210 and VK247 population [PDF]

, 2013
Yang Cheng, Daisuke Ito, Jetsumon Sattabongkot, Chae Seung Lim, Deok-Hoon Kong, Kwon‐Soo Ha, Bo Wang, Takafumi Tsuboi, Eun-Taek Han   +8 more
openalex   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

ChimLeish, a new recombinant chimeric protein evaluated as a diagnostic and prognostic marker for visceral leishmaniasis and human immunodeficiency virus coinfection. [PDF]

Parasitol Res, 2021
Galvani NC, Machado AS, Lage DP, Freitas CS, Vale DL, de Oliveira D, Ludolf F, Ramos FF, Fernandes BB, Luiz GP, Mendonça DVC, Oliveira-da-Silva JA, Reis TAR, Tavares GSV, Chaves AT, Guimarães NS, Tupinambás U, Cota GF, Humbert MV, Martins VT, Christodoulides M, Coelho EAF, Machado-de-Ávila RA.   +22 more
europepmc   +1 more source

Epitope Mapping of BmpA and BBK32 Borrelia burgdorferi Sensu Stricto Antigens for the Design of Chimeric Proteins with Potential Diagnostic Value

, 2023
Weronika Grąźlewska, Lucyna Holec-Gąsior, Karolina Sołowińska, Tomasz Chmielewski, Beata Fiecek, Marinela Contreras   +5 more
openalex   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Enhanced Immunogenicity and Protective Effects against SARS-CoV-2 Following Immunization with a Recombinant RBD-IgG Chimeric Protein. [PDF]

Vaccines (Basel)
Silva MO, Castro-Amarante MF, Venceslau-Carvalho AA, Almeida BDS, Daher IP, Souza-Silva GA, Yamamoto MM, Koike G, de Souza EE, Wrenger C, Ferreira LCS, Boscardin SB.   +11 more
europepmc   +1 more source