Results 1 to 10 of about 44,369 (236)
Halfway to Automated Feeding of Chinese Hamster Ovary Cells [PDF]
Sensors, 2023 This paper presents a comprehensive study on the development of models and soft sensors required for the implementation of the automated bioreactor feeding of Chinese hamster ovary (CHO) cells using Raman spectroscopy and chemometric methods.
Simon Tomažič, Igor Škrjanc
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Advances of Glycometabolism Engineering in Chinese Hamster Ovary Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 As the most widely used mammalian cell line, Chinese hamster ovary (CHO) cells can express various recombinant proteins with a post translational modification pattern similar to that of the proteins from human cells.
Huan-Yu Zhang +5 more
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Enhancing recombinant antibody yield in Chinese hamster ovary cells [PDF]
Tzu Chi Medical JournalA range of recombinant monoclonal antibodies (rMAbs) have found application in treating diverse diseases, spanning various cancers and immune system disorders.
Chee-Hing Yang, Hui-Chun Li, Shih-Yen Lo
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Glycoengineering Chinese hamster ovary cells: a short history. [PDF]
Biochem Soc Trans, 2021 Biotherapeutic glycoproteins have revolutionised the field of pharmaceuticals, with new discoveries and continuous improvements underpinning the rapid growth of this industry. N-glycosylation is a critical quality attribute of biotherapeutic glycoproteins that influences the efficacy, half-life and immunogenicity of these drugs.
Donini R, Haslam SM, Kontoravdi C.
europepmc +6 more sources
Mitotic spindle proteomics in Chinese hamster ovary cells.
PLoS ONE, 2011 Mitosis is a fundamental process in the development of all organisms. The mitotic spindle guides the cell through mitosis as it mediates the segregation of chromosomes, the orientation of the cleavage furrow, and the progression of cell division.
Mary Kate Bonner +5 more
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Transient light-activated gene expression in Chinese hamster ovary cells [PDF]
BMC Biotechnology, 2021 Background Chinese hamster ovary (CHO) cells are widely used for industrial production of biopharmaceuticals. Many genetic, chemical, and environmental approaches have been developed to modulate cellular pathways to improve titers. However, these methods
Shiaki A. Minami, Priya S. Shah
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Serum-Free Medium for Recombinant Protein Expression in Chinese Hamster Ovary Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 At present, nearly 70% of recombinant therapeutic proteins (RTPs) are produced by Chinese hamster ovary (CHO) cells, and serum-free medium (SFM) is necessary for their culture to produce RTPs.
Weifeng Li +4 more
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Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
Journal of Visualized Experiments, 2022 Recombinant monoclonal antibodies bind specific molecular targets and, subsequently, induce an immune response or inhibit the binding of other ligands. However, monoclonal antibody functionality and half-life may be reduced by the type and distribution of host-specific glycosylation. Attempts to produce superior antibodies have inspired the development
Marbiah, M +7 more
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Data in Brief, 2020 The data presented in this article relates to the manuscript entitled ‘Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production’, published in the Journal Metabolic ...
James D. Budge +11 more
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Proteomic Analysis of Chinese Hamster Ovary Cells [PDF]
Journal of Proteome Research, 2012 To complement the recent genomic sequencing of Chinese hamster ovary (CHO) cells, proteomic analysis was performed on CHO cells including the cellular proteome, secretome, and glycoproteome using tandem mass spectrometry (MS/MS) of multiple fractions obtained from gel electrophoresis, multidimensional liquid chromatography, and solid phase extraction ...
Deniz, Baycin-Hizal +17 more
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