Results 11 to 20 of about 5,769,168 (249)
A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells [PDF]
, 2013 Biopharmaceutical production through transient gene expression (TGE) is used within industry for the rapid supply of product for early stage testing.
Mozley, O L
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Adaptation to suspension growth: analysing the surface of suspension growth adapted Chinese hamster ovary cells [PDF]
, 2013 Many bio-pharmaceutical production processes are based upon the use of mammalian cell lines, such as Chinese hamster ovary (CHO) cells, capable of proliferation as single cells in suspension in a synthetic environment.
Walther, Christa G
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Haematologica, 2018 Immune responses to factor VIII remain the greatest complication in the treatment of severe hemophilia A. Recent epidemiological evidence has highlighted that recombinant factor VIII produced in baby hamster kidney cells is more immunogenic than factor ...
Jesse D. Lai +7 more
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Transient light-activated gene expression in Chinese hamster ovary cells
BMC Biotechnology, 2021 Background Chinese hamster ovary (CHO) cells are widely used for industrial production of biopharmaceuticals. Many genetic, chemical, and environmental approaches have been developed to modulate cellular pathways to improve titers. However, these methods
Shiaki A. Minami, Priya S. Shah
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Apoptosis in batch cultures of Chinese Hamster Ovary cells [PDF]
Biotechnology and Bioengineering, 1999 One of the main problems in the culture of Chinese Hamster Ovary (CHO) cells continues to be the inability to maintain the viability of the cultures over an extended period of time. The rapid decline in viability at the end of the culture is exacerbated by the absence of serum.
J, Goswami +4 more
openaire +2 more sources
1H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture [PDF]
, 2013 We report an NMR based approach to determine the metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture by investigating the extracellular cell culture media and intracellular metabolome of CHOK1 and CHO-S cells ...
Mark J. Howard (443860) +14 more
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Current Therapeutic Research, 2014 Objective: We aimed to assess the therapeutic efficacy of differentially modified soluble receptor for advanced glycation end products (sRAGE) in vivo using vessel ultrasound sonography and to compare the sonography data with those from postmortem ...
Hyun-Jin Tae, DVM, PhD +6 more
doaj +1 more source
Model-based analysis of N-glycosylation in Chinese hamster ovary cells. [PDF]
PLoS ONE, 2017 The Chinese hamster ovary (CHO) cell is the gold standard for manufacturing of glycosylated recombinant proteins for production of biotherapeutics. The similarity of its glycosylation patterns to the human versions enable the products of this cell line ...
Frederick J Krambeck +3 more
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CHO microRNA engineering is growing up : recent successes and future challenges [PDF]
, 2013 microRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of
Grillari, Johannes +12 more
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Generation of induced pluripotent stem cells from Chinese hamster embryonic fibroblasts
Stem Cell Research, 2017 We derived a stable cell line from Chinese hamster embryonic fibroblasts by transduction of four mouse transcription factors (M3O, Sox2, Klf4, and n-Myc) using a lentiviral vector.
Haiyun Pei +7 more
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