Results 211 to 220 of about 83,358 (225)
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Proline biosynthesis: Multiple defects in Chinese hamster ovary cells
Biochemical and Biophysical Research Communications, 1973Abstract The biochemical basis for the proline requirement of Chinese hamster ovary cells has been investigated. The results indicate an absence of conversion of glutamate to proline and a 90% reduction in ornithine transaminase, the first enzyme in the pathway converting ornithine to proline.
D, Valle +3 more
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A Chinese hamster ovary cell mutant resistant to aphidicolin
Cell Biology International Reports, 1985A triple (aphr ara-Ar and araCr) mutant (AP7) of Chinese hamster ovary cells resistant to DNA polymerase inhibitors is described. The aphidicolin-resistance of the mutant was stable and inherited as a dominant genetic trait. The DNA polymerase alpha from the wild type (aphs) and the mutant (aphr) cells differed in their elution profiles on DEAE ...
D B, Smith, N C, Mishra
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Genomic Exploration on Chinese Hamster Ovary Cells
2004Industrially important recombinant CHO cell clones carry many desirable phenotypic traits that differentiate them from the parental clone. The molecular basis for these traits at the genomic level is not well understood. A better understanding of key genetic alterations related to these traits will greatly facilitate the development of new cell lines ...
M. De Leon Gatti +13 more
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The selection of virus-resistant Chinese hamster ovary cells
Cell, 1976We have selected Chinese hamster ovary (CHO) cells resistant to infection by encephalomycarditis (EMC) virus. Thus far, we have obtained five lines resistant to EMC, all of which manifest different phenotypes. Three of the five are not persistently infected with virus, while two lines produce infectious virus and grow in its presence.
R, Taber, V, Alexander, N, Wald
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Voltage-dependent ionic conductances in Chinese hamster ovary cells
American Journal of Physiology-Cell Physiology, 1994Chinese hamster ovary (CHO) cells are becoming a widely used biological material. A number of studies report membrane ion conductance changes after transfection of channels and receptors, but there are few data available on the properties of membrane ion conductances of CHO cells before transfection.
R, Skryma +3 more
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Genetic characterization of methotrexate-resistant chinese hamster ovary cells
In Vitro, 1976In a previous report, we described the selection and partial characterization of three methotrexate (Mtx)-resistant Chinese hamster ovary cells (CHO) (1). Class I cells contained an apparent structural alteration in dihydrofolate reductase. Class II cells had an alteration affecting the permeability of the drug.
W F, Flintoff +2 more
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Temperature-induced homeoviscous adaptation of chinese hamster ovary cells
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1981Exponential and plateau phase Chinese hamster ovary cells were maintained for 3 days at 32, 37, 39 or 41 degrees C. The effect of growth temperature on the fluidity and composition of the cellular membranes, and on the ability of the cells to resist a subsequent heat treatment at 43 degrees C, was measured.
R L, Anderson +3 more
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Cellular ATP Content of Heated Chinese Hamster Ovary Cells
Radiation Research, 1984Hyperthermia at either 41.5 or 45 degrees C with variable heating times to reduce cell survival up to three orders of magnitude did not decrease significantly cellular ATP content when measured either immediately or up to 7 hr after a heat treatment. Similarly, cellular ATP content was not significantly reduced with step-down heating, precooling prior ...
K J, Henle +3 more
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[Codon usage of Chinese hamster ovary cells.].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2016To investigate the optimal codons of dihydrofolate reductase (dhfr) minus Chinese hamster ovary cells (CHO dhfr-).A cDNA library of CHO dhfr- containing high abundence mRNA was constructed and protein-coding sequences were obtained after identification and analysis. Codon frequence of CHO dhf- was compared with that of Chinese hamster in CUTG database.
Z Y, Wang +6 more
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REFERENCE RECOMBINANT CHINESE HAMSTER OVARY CELL LINES
In Vitro Cellular & Developmental Biology - Animal, 2001C H, Liu, I M, Chu, S M, Hwang
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