Keratoconus (KC) is a complex ocular disease that is affected by both genetic and non-genetic triggers. A recent genome-wide association study (GWAS) identified a genome-wide significant locus for KC in the region of PNPLA2 (rs61876744), as well as a ...
Jing Zhang +11 more
doaj +1 more source
Body weights in Han Chinese populations
The body weights of 26,954 Han Chinese adults in 67 areas (16,503 in rural areas and 10,451 in urban areas) across China were measured from 2009 to 2013. The results showed that in China, the three areas (north China, northeast China, and Jianghuai Plain) were with the greatest body weight. Northwest Han Chinese populations were heavier.
Yonglan Li +11 more
openaire +1 more source
Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population
Background Evidence from genetic epidemiology indicates that type 2 diabetes (T2D) has a strong genetic basis. Activated STAT4 has an inflammatory effect, and STAT4 is an important mediator of inflammation in diabetes.
Jiaqi Cui +12 more
doaj +1 more source
Genome-wide association study of serum tumor markers in Southern Chinese Han population
Background Serum indicators AFP, CA50, CA125, CA153, CA19-9, CEA, f-PSA, SCC-Ag have been confirmed as tumor markers (TMs). We conducted a genome-wide association study on 8 tumor markers of our 427 Han population in southern China, in order to identify ...
Xiukuan Li +13 more
doaj +1 more source
Spectrum of malignancies among the population of adults living with HIV infection in China: A nationwide follow-up study, 2008-2011. [PDF]
BackgroundAlthough increasingly studied in high-income countries, there is a paucity of data from the Chinese population on the patterns of cancer among people living with HIV (PLHIV).MethodsWe conducted a nationwide follow-up study using routinely ...
Detels, Roger +7 more
core +2 more sources
Objective: Leprosy and tuberculosis (TB) are chronic granulomatous infectious diseases. As well as pathogen and environmental factors, host genetic factors make a substantial contribution to susceptibility to both diseases.
Chuan Wang +7 more
doaj +1 more source
Forensic characterization and genetic polymorphisms of 19 X-chromosomal STRs in 1344 Han Chinese individuals and comprehensive population relationship analyses among 20 Chinese groups. [PDF]
X-chromosomal short tandem repeats (X-STRs) may assist resolution of complex forensic kinship cases and complement autosomal and Y-chromosomal STRs in routine forensic practice and population genetics.
Pengyu Chen +8 more
doaj +1 more source
Association Between Snoring and Diabetes Among Pre- and Postmenopausal Women
Yun Yuan,1 Fan Zhang,1 Jingfu Qiu,1 Liling Chen,2 Meng Xiao,1 Wenge Tang,2 Qinwen Luo,1 Xianbin Ding,2 Xiaojun Tang1 1School of Public Health and Management, Medical and Social Development Research Center, Chongqing Medical University, Chongqing, 400016,
Yuan Y +8 more
doaj
POLG Mutations Are Probably Rare in the Han Chinese Population [PDF]
Objective Mutations in polymerase gamma gene (POLG) are believed to be an important cause of early and juvenile onset of non-syndromic intractable epilepsy. The aim of this study is to investigate the incidence/prevalence of POLG pathogenic variants in epilespy patients of Han population through sequencing it.Methods Han Chinese patients with seizures ...
Kun Fang, Yang +7 more
openaire +2 more sources
The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population [PDF]
The c.G4883C variant in the leucine-rich repeat kinase 2 (LRRK2) gene (protein effect: Arg1628Pro) has been recently proposed as a second risk factor for sporadic Parkinson's disease in the Han Chinese population (after the Gly2385Arg variant).
A Fonzo Di +32 more
core +4 more sources

