Hereditary Breast Cancer in the Han Chinese Population
Journal of Epidemiology, 2013 Breast cancer is the most common malignancy among women and has a strong genetic background. So far, 13 breast cancer susceptibility genes of high or moderate penetrance have been identified. This review summarizes findings on these genes in Han Chinese. BRCA1 and BRCA2 are the 2 most important susceptibility genes.
Cao, Wenming +2 more
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Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations
Hereditas, 2018 Background Han Chinese, Japanese and Korean, the three major ethnic groups of East Asia, share many similarities in appearance, language and culture etc., but their genetic relationships, divergence times and subsequent genetic exchanges have not been ...
Yuchen Wang +3 more
doaj +1 more source
B7-H4gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population [PDF]
, 2009 Background B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity.
Jie Zhang +34 more
core +2 more sources
Nagashima-type palmoplantar keratosis in a Chinese Han population
Molecular Medicine Reports, 2016 Nagashima-type palmoplantar keratosis (NPPK) is an autosomal recessive form of palmoplantar keratoderma (PPK), which is caused by mutations in the SERPINB7 gene. NPPK has only been reported in Japanese and Chinese populations. The present study was conducted on 12 unrelated Chinese patients who were clinically predicted to suffer from NPPK.
Zhang, Jia +6 more
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A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet’s disease in a Chinese Han population [PDF]
International Journal of Ophthalmology, 2021 AIM: To explore the association of single nucleotide polymorphisms (SNPs) in the IL33/IL1RL1 gene region with the susceptibility to Behcet's disease (BD) in a Chinese Han population. METHODS: A total of eight SNPs in the candidate gene region (rs11792633,
Xin-Shu Liu +9 more
doaj +1 more source
New insights from GWAS for the cleft palate among han Chinese population [PDF]
, 2017 Genome wide association studies (GWAS) already have identified tens of susceptible loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P).
Duan, Shi Jun +8 more
core +1 more source
Using Ancient Samples in Projection Analysis. [PDF]
, 2015 Projection analysis is a tool that extracts information from the joint allele frequency spectrum to better understand the relationship between two populations.
Slatkin, Montgomery, Yang, Melinda A
core +3 more sources
A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort [PDF]
, 2011 Background Synaptic genes, NLGN3 and NLGN4X, two homologous members of the neuroligin family, have been supposed as predisposition loci for autism spectrum disorders (ASDs), and defects of these two genes have been identified in a small ...
Jindan Yu +5 more
core +2 more sources
A functional polymorphism in the gene is associated with asthma in a Chinese Han Population [PDF]
, 2009 Background Mutation in SPINK5 causes Netherton syndrome, a rare recessive skin disease that is accompanied by severe atopic manifestations including atopic dermatitis, allergic rhinitis, asthma, high serum IgE and hypereosinophilia.
Qiji Liu +30 more
core +2 more sources
Haplotype diversity in mitochondrial genome in a Chinese Han population [PDF]
Journal of Human Genetics, 2016 Investigations into the use of mitochondrial genome (mtGenome) typing by massively parallel sequencing technologies are well underway in many areas, including forensic genetics. Previous studies have demonstrated that mtGenome sequencing data generated from Ion torrent personal genome machine (PGM) system were highly viable and reliable in forensic ...
Ke, Ma +5 more
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