Results 61 to 70 of about 339,190 (282)

RETRACTED: Population genetics of 24 Y‐STR loci in Chinese Han population from Jilin Province, Northeast China

Molecular Genetics & Genomic Medicine, 2019
Background It is meaningful to expand the available population information on forensic medicine and to investigate the genetic characteristics of Han population from Jilin Province, Northeast China.
Xiao‐ming Xu, Ji‐long Zheng, Yin Lou, Xiao‐han Wei, Bao‐jie Wang, Jun Yao   +5 more
doaj   +1 more source

Population Genetic Analysis of Modern and Ancient DNA Variations Yields New Insights Into the Formation, Genetic Structure, and Phylogenetic Relationship of Northern Han Chinese

Frontiers in Genetics, 2019
Modern East Asians derived from the admixture of aborigines and incoming farmers expanding from Yellow and Yangtze River Basins. Distinct genetic differentiation and subsequent admixture between Northeast Asians and Southeast Asians subsequently ...
Pengyu Chen, Pengyu Chen, Jian Wu, Jian Wu, Li Luo, Li Luo, Hongyan Gao, Hongyan Gao, Mengge Wang, Xing Zou, Yingxiang Li, Gang Chen, Haibo Luo, Limei Yu, Yanyan Han, Fuquan Jia, Guanglin He   +16 more
doaj   +1 more source

Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population [PDF]

, 2016
TBX21 recode T-bet which is an important transcription factor that drives the Th1 immune response primarily by promoting expression of the interferon-gamma (IFNG) gene.
Leng, RX, Li, XM, Li, XP, Liu, J, Pan, HF, Tao, SS, Wang, DG, Yang, W, Yang, XK, Ye, DQ, Zhang, C   +10 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Testing and comparing two self-care-related instruments among older Chinese adults [PDF]

, 2017
Objectives The study aimed to test and compare the reliability and validity, including sensitivity and specificity of the two self-care-related instruments, the Self-care Ability Scale for the Elderly (SASE), and the Appraisal of Self-care Agency Scale ...
A Millar, AL Comfrey, BF Damásio, BY Kearney, CL Wong, D. L. Streiner, Daniel Serrani Azcurra, DE Orem, EJ Pedhazur, GC Evers, GX Zeng, H Gao, H Gao, Han Gao, HH Wang, JA Zauszniewski, Jacqueline McCallum, JC Nunally, JW Osborne, JZ Shi, K Sundsli, Kun Liu, L Guo, L Guo, L Robinson, Lina Guo, LN Guo, M Lorensen, M Lorensen, M Zhou, MH Almeida, MS Fok, O Söderhamn, O Söderhamn, O Söderhamn, O Söderhamn, O Söderhamn, Qiyun Guo, RW Brislin, ST Tomstad, ST Tomstad, T van Achterberg, Ulrika Söderhamn, VD Sousa, X Wang, X Wang, XG Wang, Xianfei Ding, Yanjin Liu, YL Gao, ZS Nasreddine   +50 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Comparison of Reform-Era Labor Force Participation Rates of China’s Ethnic Minorities and Han Majority [PDF]

, 2005
Previous research suggests that minorities are not faring well in China’s transition—both income and occupational attainment gaps are widening. We are particularly interested in whether the differences in majority and minority economic outcomes are the ...
Hughes, James W., Maurer-Fazio, Margaret, Zhang, Dandan   +2 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source