Results 71 to 80 of about 771,775 (343)

Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. [PDF]

, 2008
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldTo determine if neuregulin 1 (NRG1) is associated with schizophrenia in Asian populations, we investigated a Han Chinese population using both a
Cai, G, Collier, D A, Gudfinnsson, E, Gudnadottir, V G, Gulcher, J R, Ingason, A, Januel, D, Li, T, Liu, X, Murray, R M, Petursson, H, Stefansson, H, Stefansson, K, Steinthorsdottir, V   +13 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

RETRACTED: Population genetics of 24 Y‐STR loci in Chinese Han population from Jilin Province, Northeast China

Molecular Genetics & Genomic Medicine, 2019
Background It is meaningful to expand the available population information on forensic medicine and to investigate the genetic characteristics of Han population from Jilin Province, Northeast China.
Xiao‐ming Xu, Ji‐long Zheng, Yin Lou, Xiao‐han Wei, Bao‐jie Wang, Jun Yao   +5 more
doaj   +1 more source

Population Genetic Analysis of Modern and Ancient DNA Variations Yields New Insights Into the Formation, Genetic Structure, and Phylogenetic Relationship of Northern Han Chinese

Frontiers in Genetics, 2019
Modern East Asians derived from the admixture of aborigines and incoming farmers expanding from Yellow and Yangtze River Basins. Distinct genetic differentiation and subsequent admixture between Northeast Asians and Southeast Asians subsequently ...
Pengyu Chen, Pengyu Chen, Jian Wu, Jian Wu, Li Luo, Li Luo, Hongyan Gao, Hongyan Gao, Mengge Wang, Xing Zou, Yingxiang Li, Gang Chen, Haibo Luo, Limei Yu, Yanyan Han, Fuquan Jia, Guanglin He   +16 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population

Mediators of Inflammation, 2016
Objective. To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. Methods. Ninety UC patients and 30 healthy subjects were enrolled.
Yang Gong, Yi-fan Lin, Ning Zhao, Xiaojuan He, A. Lu, Wei Wei, M. Jiang   +6 more
semanticscholar   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Testing and comparing two self-care-related instruments among older Chinese adults [PDF]

, 2017
Objectives The study aimed to test and compare the reliability and validity, including sensitivity and specificity of the two self-care-related instruments, the Self-care Ability Scale for the Elderly (SASE), and the Appraisal of Self-care Agency Scale ...
A Millar, AL Comfrey, BF Damásio, BY Kearney, CL Wong, D. L. Streiner, Daniel Serrani Azcurra, DE Orem, EJ Pedhazur, GC Evers, GX Zeng, H Gao, H Gao, Han Gao, HH Wang, JA Zauszniewski, Jacqueline McCallum, JC Nunally, JW Osborne, JZ Shi, K Sundsli, Kun Liu, L Guo, L Guo, L Robinson, Lina Guo, LN Guo, M Lorensen, M Lorensen, M Zhou, MH Almeida, MS Fok, O Söderhamn, O Söderhamn, O Söderhamn, O Söderhamn, O Söderhamn, Qiyun Guo, RW Brislin, ST Tomstad, ST Tomstad, T van Achterberg, Ulrika Söderhamn, VD Sousa, X Wang, X Wang, XG Wang, Xianfei Ding, Yanjin Liu, YL Gao, ZS Nasreddine   +50 more
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source