Results 91 to 100 of about 92,663 (299)

Evaluating the transferability of Hapmap SNPs to a Singapore Chinese population

BMC Genetics, 2010
Background The International Hapmap project serves as a valuable resource for human genome variation data, however its applicability to other populations has yet to be exhaustively investigated.
Wang De Yun, Nilkanth Pallavi, Anantharaman Ramani, Andiappan Anand, Chew Fook   +4 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Genetic Variability of TCF4 in Schizophrenia of Southern Chinese Han Population: A Case-Control Study

Frontiers in Genetics, 2019
Objective: Schizophrenia is thought to be a neurodevelopmental disorder. As a key regulator in the development of the central nervous system, transcription factor 4 (TCF4) has been shown to be involved in the pathogenesis of schizophrenia. The aim of our
Jingwen Yin, Dongjian Zhu, You Li, You Li, Dong Lv, Huajun Yu, Chunmei Liang, Chunmei Liang, Xudong Luo, Xusan Xu, Jiawu Fu, Haifeng Yan, Zhun Dai, Xia Zhou, Xia Wen, Susu Xiong, Zhixiong Lin, Juda Lin, Bin Zhao, Yajun Wang, Keshen Li, Keshen Li, Keshen Li, Guoda Ma, Guoda Ma   +24 more
doaj   +1 more source

Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population

, 2012
The multiple small-scale association studies of candidate genes for type 2 diabetes mellitus in the Chinese Han population have shown inconsistent results.
Han Xueyao, Chen Jing, Ji Linong
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Genetic diversity and forensic characteristics of 15 autosomal short tandem repeats in Tibet highland and Guangdong lowland Han Chinese populations

Annals of Human Biology, 2019
Background: Much attention has been paid to the genetic variants of microsatellites in East Asian populations; however, genetic diversity of high-altitude adaptation in Tibet Han remains largely uncharacterised.
Guanglin He, Bo Gao, Jianxin Guo, Yongdong Su   +3 more
doaj   +1 more source

TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population

Oncotarget, 2017
Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 healthy individuals, after which their associations ...
Liu, Lijun, Li, Jingjie, Yan, Mengdan, Li, Jing, Chen, Junyu, Zhang, Yi, Zhu, Xikai, Wang, Li, Kang, Longli, Yuan, Dongya, Jin, Tianbo   +10 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Effects of CYP3A4 Polymorphisms on Drug Addiction Risk Among the Chinese Han Population

Frontiers in Public Health, 2019
Background:Cytochrome P450 3A4 (CYP3A4) regulates pharmacokinetic and pharmacodynamic interactions during the process of drug absorption and metabolism, suggesting CYP3A4 plays an important role in drug addiction.
Li Wang, Li Wang, Mei Bai, Mei Bai, Tianbo Jin, Tianbo Jin, Jianwen Zheng, Jianwen Zheng, Yuhe Wang, Yuhe Wang, Yongjun He, Yongjun He, Dongya Yuan, Dongya Yuan, Xue He, Xue He   +15 more
doaj   +1 more source