Results 101 to 110 of about 771,775 (343)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Genetic polymorphisms of cell adhesion molecules in Behcet’s disease in a Chinese Han population
Scientific Reports, 2016 Cell adhesion molecules (CAMs) are involved in various immune-mediated diseases. This study was conducted to investigate the association of single nucleotide polymorphisms (SNPs) of CAMs with Behçet’s disease (BD) in a Chinese Han population. A two-stage
M. Zheng +9 more
semanticscholar +1 more source
Ischemic stroke susceptibility gene in a Northern Han Chinese population.
Neural regeneration research, 2013 Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the -607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China,
Wang, Haiping +6 more
openaire +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Association of RPS26 gene polymorphism with different types of diabetes in Chinese individuals
Journal of Diabetes InvestigationAims/Introduction Different types of diabetes show distinct genetic characteristics, but the specific genetic susceptibility factors remain unclear. Our study aimed to explore the associations between the ribosomal protein S26 (RPS26) gene rs1131017 ...
Rong Song +12 more
doaj +1 more source
Oldest Old Mortality in China [PDF]
We find that the Kannisto model, a two-parameter logistic formula, fits Han Chinese death rates at oldest-old ages better than the Gompertz and four other models. Chinese death rates appear to be roughly similar to Swedish and Japanese rates after age 97
James W. Vaupel, Yi Zeng
core
Genetic variants associated with skin aging in the Chinese Han population.
Journal of dermatological science (Amsterdam), 2017 BACKGROUND The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations.
Wenshan Gao +10 more
semanticscholar +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Cancer Management and Research, 2018 Chuanyin Li,1,* Xiaona Wang,1,* Yingfu Li,2 Xinwen Zhang,1 Mingbo Sun,1 Shuyuan Liu,1 Le Sun,3 Li Shi,1 Yufeng Yao1 1Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China; 2Department ...
Li C +8 more
doaj