Results 51 to 60 of about 5,795,971 (345)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Single electron tunneling through high-Q single-wall carbon nanotube NEMS resonators

, 2010
By first lithographically fabricating contact electrodes and then as last step growing carbon nanotubes with chemical vapour deposition across the ready-made chip, many potential contamination mechanisms for nanotube devices can be avoided.
Cao, Deshpande, Goldhaber-Gordon, Goldhaber-Gordon, Hüttel, Jarillo-Herrero, Jarillo-Herrero, Jensen, Kong, Kuemmeth, Lassagne, Lu, O'Connell, Oreg, Pashkin, Poot, Sapmaz, Sazonova, Schwab, Steele, Steele, Treacy, Witkamp, Yu   +23 more
core   +1 more source

Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [PDF]

, 2019
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself.
Casadesús Pursals, Josep, García Pastor, Lucía, Jakomin, Marcello, Puerta Fernández, Elena, Sánchez Romero, María Antonia   +4 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Fluorescence monitoring of capilarry electrophoresis separation in a lab-on-a-chip with monolithically integrated waveguides [PDF]

, 2008
Femtosecond-laser-written optical waveguides were monolithically integrated into a commercial lab-on-a-chip to intersect a microfluidic channel. Laser excitation through these waveguides confines the excitation window to a width of 12 μm, enabling high ...
Besselink, G.A.J., Cerullo, G., Dekker, R., Dongre, C., Hoekstra, H.J.W.M., Martinez-Vazquez, R., Osellame, R., Pollnau, M., Ramponi, R., Vlekkert, H.H. van den, Weeghel, R. van   +10 more
core   +1 more source

Control of crystal polymorph in microfluidics using molluscan 28 kDa Ca2+-binding protein [PDF]

, 2010
Biominerals produced by biological systems in physiologically relevant environments possess extraordinary properties that are often difficult to replicate under laboratory conditions.
Cusack, M., Dobson, P.S., Freer, A., Gadegaard, N., Ji, B., Yin, H.   +5 more
core   +1 more source

Numerical Methods for the Modelling of Chip Formation

Archives of Computational Methods in Engineering, 2020
The modeling of metal cutting has proved to be particularly complex due to the diversity of physical phenomena involved, including thermo-mechanical coupling, contact/friction and material failure.
J. M. Rodriguez, J. Carbonell, P. Jonsén   +2 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

InP nanocrystals on silicon for optoelectronic applications

, 2012
One of the solutions enabling performance progress, which can overcome the downsizing limit in silicon technology, is the integration of different functional optoelectronic devices within a single chip. Silicon with its indirect band gap has poor optical
Helm, Manfred, Liedke, Maciej Oskar, Mücklich, Arndt, Ou, Xin, Prucnal, Slawomir, Pyszniak, Krzysztof, Reuther, Helfried, Skorupa, Wolfgang, Turek, Marcin, Zhou, Shengqiang, Zuk, Jerzy   +10 more
core   +1 more source