Results 121 to 130 of about 10,800 (238)

Organocatalyzed diastereo- and enantioselective synthesis of N–N atropisomeric isoindolinones bearing central chirality

Nature Communications
Methods for catalytically constructing of N–N axially chiral scaffolds have garnered significant attention since such compounds are widely present in natural products, bioactive molecules, and organic materials.
Xingguang Li, Xin-Ze Wang, Boming Shen, Qian-Yu Chen, Huijing Xiang, Peiyuan Yu, Pei-Nian Liu   +6 more
doaj   +1 more source

Phosphoramidate and Silyl Amine Mediated Synthesis of Isocyanide Cyclopentadienone Iron Complexes

Helvetica Chimica Acta, Volume 109, Issue 3, March 2026.
Carbonyl ligands in cyclopentadienone iron complexes are replaced by isocyanide ligands without using free, malodorous isocyanides. The reaction takes place via an Aza‐Wittig‐type reaction starting from primary amines, employing either phosphoramidates or silyl amines as intermediate reagents.
André Bütikofer, Daniel Svoboda, Joël Landis, Peter Chen   +3 more
wiley   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Turn‐Induction in Peptides Incorporating Novel Cyrene‐Derived α,α‐Disubstituted Amino Acid

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Novel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Kajumee Bora Bhowal, Raphael Hitti, William D. Lubell   +2 more
wiley   +1 more source

Endo-Functionalized Cyclic Oligophenylenes: Synthesis and Complexation with a Chiral Phosphoric Acid. [PDF]

ACS Omega, 2022
Ono K, Tanaka Y, Sugimoto K, Kinubari S, Kawai H.   +4 more
europepmc   +1 more source

Ions as Architects of DNA Nanostructures: Mechanisms, Simulations, and Technological Frontiers

Small Structures, Volume 7, Issue 3, March 2026.
Ions are not merely passive electrolytes but active regulators of DNA nanostructures. This review shows how ion valence, hydration, and specificity govern electrostatic screening, correlation, and confinement, enabling DNA origami, metallized DNA, nanopores, hydrogels, DNAzymes, molecular machines, and energy devices through integrated experimental and
Sergiy Perepelytsya, Dmytro Piatnytskyi, Tetiana Bubon, Narcis Cibotariu, Aatto Laaksonen, Francesca Mocci   +5 more
wiley   +1 more source

Validated ligand geometries for macromolecular refinement restraints and molecular‐mechanics force fields

Acta Crystallographica Section D, Volume 82, Issue 3, Page 216-226, March 2026.
A database of validated ligand restraints computed using various levels of quantum mechanics is generated and distributed with Phenix to streamline and improve macromolecular refinement results.In macromolecular structure refinement, the low observation‐to‐parameter ratio and the lack of high‐resolution data are countered by using a priori information ...
Nigel W. Moriarty, David A. Case, Dorothee Liebschner, Paul D. Adams   +3 more
wiley   +1 more source

Data Science Enables the Development of a New Class of Chiral Phosphoric Acid Catalysts. [PDF]

Chem, 2023
Liles JP, Rouget-Virbel C, Wahlman JLH, Rahimoff R, Crawford JM, Medlin A, O'Connor V, Li J, Roytman VA, Toste FD, Sigman MS.   +10 more
europepmc   +1 more source

Thermotolerant D‐Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)‐3‐Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang, Bin Zhi, Zhenyu Xie, Beibei Zhang, Ning Wang, Wanpeng Wang   +5 more
wiley   +1 more source

MATEO: intermolecular α-amidoalkylation theoretical enantioselectivity optimization. Online tool for selection and design of chiral catalysts and products

Journal of Cheminformatics
The enantioselective Brønsted acid-catalyzed α-amidoalkylation reaction is a useful procedure is for the production of new drugs and natural products.
Paula Carracedo-Reboredo, Eider Aranzamendi, Shan He, Sonia Arrasate, Cristian R. Munteanu, Carlos Fernandez-Lozano, Nuria Sotomayor, Esther Lete, Humberto González-Díaz   +8 more
doaj   +1 more source