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Kinetic Resolution of Secondary Alcohols Catalyzed by Chiral Phosphoric Acids
Angewandte Chemie, 2013A new electronically tuned binaphthyl-based phosphoric acid is developed, that, in contrast to conventional methods, allows the kinetic resolution of a broad range of secondary alcohols without the need of stoichiometric amounts of base.
Shingo, Harada +4 more
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Chiral Phosphoric Acid‐Catalyzed Atroposelective Synthesis of Axially Chiral Aminophosphines
Chinese Journal of ChemistryComprehensive SummaryP,N‐Atropisomers are valuable structural motifs, widely utilized as chiral ligands and in various catalytic systems. However, the asymmetric synthesis of these compounds from readily available starting materials remains a significant challenge.
Zi‐Han Wang +5 more
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Phosphoric Acid-Catalyzed Enantioselective Synthesis of Axially Chiral Cyclobutanamides
Organic LettersChiral cyclobutanamide is a privileged scaffold in drug discovery. Here, we describe, for the first time, the synthesis of axially chiral cyclobutanamides via phosphoric acid-catalyzed enantioselective condensation between N-arylcarbamyl cyclobutanones and hydroxylamines.
Guang Cheng +6 more
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Chemical Reviews
Chiral phosphoric acids (CPAs) have emerged as highly effective Brønsted acid catalysts in an expanding range of asymmetric transformations, often through novel multifunctional substrate activation modes. Versatile and broadly appealing, these catalysts benefit from modular and tunable structures, and compatibility with additives.
Isaiah O. Betinol +3 more
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Chiral phosphoric acids (CPAs) have emerged as highly effective Brønsted acid catalysts in an expanding range of asymmetric transformations, often through novel multifunctional substrate activation modes. Versatile and broadly appealing, these catalysts benefit from modular and tunable structures, and compatibility with additives.
Isaiah O. Betinol +3 more
openaire +2 more sources
Aporphinol-Derived Chiral Phosphoric Acids: Synthesis and Catalytic Performance
Organic LettersA novel series of chiral phosphoric acid (CPA) catalysts based on a bioinspired aporphinol scaffold has been developed. The efficacy of these CPAs is demonstrated through enantioselective transfer hydrogenation of C2-substituted quinolines, achieving excellent enantioselectivities (93-99% enantiomeric excess).
Jun Zhao +8 more
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