Results 11 to 20 of about 4,429,443 (158)

Evaluation and Application of Stationary Phase Selectivity for Drug Analysis [PDF]

Despite the wide range of HPLC stationary phases available for reversed-phase high-performance liquid chromatography (RP-HPLC) and the in-depth studies using probes to highlight differences between them, there is very little in the way of stationary ...
Perera, R. Wimal H.
core   +6 more sources

Dual Nickel/Photoredox-Catalyzed Regio- and Enantioselective Alkenylation of Epoxides. [PDF]

Adv Sci (Weinh)
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Lan H, Jin S, Xu ZD, Li G, Wang D.
europepmc   +2 more sources

Application of Natural and Modified Biomacromolecules in Miniaturised Separative Analytical Techniques [PDF]

In pharmaceutical R & D, drug stereochemistry, and consequently the rotation of enantiomers, is very important. Because they act as chiral selectors in vivo, biomacromolecules have been extensively used as chiral selectors for the liquid chromatographic (
Salmon, Andrew B
core   +6 more sources

Effects of Temperature and Mobile Phase Condition on Chiral Recognition of Poly(l-phenylalanine) Chiral Stationary Phase [PDF]

, 2011
Characteristics of the chiral stationary phase with poly(l-phenylalanine) peptide selector, which was in α-helical state, was reported. Since environmental factors affect peptide conformation, the changes in enantioselectivity were examined depending on ...
Ohba, Yoshihito, Wada, Mitsuhiro, Kenichiro Nakashima, Oyamada, Kana, Mitsuhiro Wada, Naotaka Kuroda, Kuroda, Naotaka, Yoshihito Ohba, Ohyama, Kaname, Nakashima, Kenichiro, Kana Oyamada, Kaname Ohyama, Kishikawa, Naoya, Naoya Kishikawa   +13 more
core   +1 more source

DFT-assisted rational design of salan ligands for highly enantioselective Zr-salan-catalyzed hydroxylation of cyclic <i>β</i>-keto esters. [PDF]

Smart Mol
Guided by DFT calculations, the design of novel C1‐symmetric salan ligands without the involvement of Suzuki coupling was achieved, and the preparation of α‐hydroxy‐β‐ketoesters in 99% yield and 99% ee was realized under low catalyst loading. Abstract In this work, a structurally simple, inexpensive, and readily accessible Zr–salan catalytic system was
Ma C, Tang K, Jiang Y, Zhu H, Wu Y, Xing Y, Wang Y, Liu Q, Du J, Meng Q.   +9 more
europepmc   +2 more sources

Preparation and characterization of poly(l-phenylalanine) chiral stationary phases with varying peptide length. [PDF]

, 2008
Three new chiral stationary phases with different lengths of l-phenylalanine peptide were prepared by solid-phase synthesis with tert-butoxycarbonyl (Boc)-l-phenylalanine on silica.
Ohba, Yoshihito, Kuroda, Naotaka, Ohyama, Kaname, Wada, Mitsuhiro, Nakashima, Kenichiro, Oyamada, Kana, Kishikawa, Naoya, Maki, Toshihide   +7 more
core   +1 more source

Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation

Angewandte Chemie, EarlyView.
The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam, Josep M. Luis, Arnau Call, Quentin Lefebvre, Matthew S. Sigman, Miquel Costas   +5 more
wiley   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Enhancement of Dissymmetry Factors Through Axial Elongation of Hetero[n]helicenes

Angewandte Chemie, EarlyView.
A benzofuran scaffolding strategy enables the synthesis of hetero[9]‐, [12]‐, and [15]helicenes. Structural and chiroptical analyses demonstrate that systematic axial elongation increases helical distortion and significantly amplifies luminescence dissymmetry.
Jeppe S. Mogensen, Christoffer Bræstrup, Christoffer Warming, Georg I. Junker, Yann Lie, Mathias Hermann, Kurt V. Mikkelsen, Michael Pittelkow   +7 more
wiley   +2 more sources

Accelerated Discovery of Topological Spin Phase Diagrams in CrSBr Magnets Via High‐Throughput Optimization

Advanced Functional Materials, EarlyView.
Here, we develop a high‐throughput algorithm that accelerates the elucidation of phase diagrams of topological spin textures using limited computational resources at high numerical accuracy. Applying this framework to the van der Waals magnet CrSBr, we unveiled a hierarchy of previously unknown topological textures (domain‐wall bimerons, bimeron chains,
Andrew Lyall, Mohammad H. Badarneh, Cristian Bonato, Rebecca Cheung, Elton J. G. Santos   +4 more
wiley   +1 more source