Machine Learning for Synthetic Organic Chemistry: Methods, Applications, and Best Practices
Artificial intelligence (AI) and machine learning (ML) are increasingly reshaping experimental chemistry. This review maps the challenges of synthetic organic chemistry to modern digital tools that can help address them. While focusing on the practical application of ML tools in real‐world laboratory settings, we outline prerequisites, emerging ...
Niklas Hölter +3 more
wiley +1 more source
Preparation of Silica-Based Chitosan Chiral Stationary Phases by Two Synthetic Approaches and Evaluation of Their Enantioseparation Performance by HPLC. [PDF]
Zhang X, Li B, Han X.
europepmc +1 more source
Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo +9 more
wiley +1 more source
Quantum Chemistry Based Simulation of Enantioseparation on Cyclodextrin- and Polysaccharide-Based Chiral Stationary Phases. [PDF]
Nelles-Ziegler L, Plett C, Grimme S.
europepmc +1 more source
Chiral Stationary Phase based on Peptoid with α-chiral, Aromatic Side Chains
Chiral Stationary Phase based on Peptoid with α-chiral, Aromatic Side ...
吴海波 +3 more
core
The coordination behavior of bis(imidazo[1,5‐a]pyridine)methane derivatives has been expanded through functionalization with a methylpyridine pendant arm, affording new tripodal N,N,N‐tridentate ligands. Upon coordination to zinc(II), the resulting (chiral) complexes retain the attractive luminescent properties of the ligand platform, displaying ...
Chiara Vola +5 more
wiley +1 more source
Enantioselective Properties of Neglected Drug Nifurtimox on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases by Green HPLC Separation Methods. [PDF]
Mohr A +4 more
europepmc +1 more source
Assessing chiral self-recognition using chiral stationary phases
[[abstract]]Chiral stationary phases were synthesized and their ability to separate racemic precursors from which they were derived was assessed. Taken in conjunction with homochiral recognition previously observed in the solid state, the results of this
James R. Carey* +8 more
core
Application of Molecular Dynamic Simulation in the Enantiorecognition Mechanism of the Pharmaceutically Relevant Leu-Phe Dipeptides With Four Zwitterionic Chiral Stationary Phases. [PDF]
Varfaj I +5 more
europepmc +1 more source
Recent progress in adsorbed stationary phases for capillary electrochromatography
This review surveys the recent progress in the adsorbed stationary phases for capillary electrochromatography (CEC). Adsorption-based methods for preparation of stationary phase are novel approaches in CEC, which allow rapid and facile preparing ...
Zou, HF, Liu, Z, Wu, R
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