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Chloride channels of intracellular organelles

Current Opinion in Cell Biology, 1995
Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula ...
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Chloride channel: Tail Wagging the Channel

Science's STKE, 1999
Improper function of the chloride channel known as the cystic fibrosis transmembrane regulator (CFTR) is associated with debilitating diseases in humans. Conductance of the channel is regulated in a complex manner. One mechanism of regulation requires phosphorylation of the channel in the so-called regulatory or R domain, which relieves an
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The Physiology of Epithelial Chloride Channels

Hospital Practice, 1989
These highly regulated channels have a rate-limiting function in secretory activity. Recent research has suggested that the regulation of chloride transport is the likely locus of the defect in cystic fibrosis and has contributed to a fuller understanding of the control of ion channels and their role in fluid and electrolyte balance.
openaire   +2 more sources

Chloride channels in epithelia

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1988
openaire   +3 more sources

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

Science, 2008
A. Caputo   +9 more
semanticscholar   +1 more source

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

Proceedings of the National Academy of Sciences of the United States of America, 2020
Merritt Maduke   +2 more
exaly  

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