Pharmacological modulation of chloride channels as a therapeutic strategy for neurological disorders [PDF]
Frontiers in Physiology, 2023 Chloride homeostasis is critical in the physiological functions of the central nervous system (CNS). Its concentration is precisely regulated by multiple ion-transporting proteins such as chloride channels and transporters that are widely distributed in ...
Zhiyu Wang, Kaylee Choi
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The Role of Chloride Channels in the Multidrug Resistance [PDF]
Membranes, 2021 Nowadays, one of medicine’s main and most challenging aims is finding effective ways to treat cancer. Unfortunately, although there are numerous anti-cancerous drugs, such as cisplatin, more and more cancerous cells create drug resistance.
Bartosz Wilczyński +3 more
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Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels [PDF]
Molecules, 2023 Many transmembrane proteins are modulated by intracellular or extracellular pH. Investigation of pH dependence generally proceeds by mutagenesis of a wide set of amino acids, guided by properties such as amino-acid conservation and structure.
Kathleen Elverson +3 more
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The role of the Smad2/3/4 signaling pathway in osteogenic differentiation regulation by ClC-3 chloride channels in MC3T3-E1 cells [PDF]
Journal of Orthopaedic Surgery and Research, 2022 Background ClC-3 chloride channels promote osteogenic differentiation. Transforming growth factor-β1 (TGF-β1) and its receptors are closely related to ClC-3 chloride channels, and canonical TGF-β1 signaling is largely mediated by Smad proteins.
Xiaolin Lu +4 more
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Role of voltage-gated chloride channels in epilepsy: current insights and future directions [PDF]
Frontiers in PharmacologyEpilepsy is a prevalent chronic neurological disorder characterised by recurrent seizures caused by excessive neuronal discharge. Disruptions in chloride ion homeostasis significantly affect neuronal excitability, and play a crucial role in the ...
Ming-Ming Ni +4 more
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Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies? [PDF]
Pharmacology Research & PerspectivesChloride channels are involved in many cellular processes, including cell volume regulation, modulation of cell excitability, and electrolyte and water secretion.
Paola Laghetti +4 more
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Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]
Elife, 2020 The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
He M +14 more
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CLC channel function and dysfunction in health and disease [PDF]
Frontiers in Physiology, 2014 CLC channels and transporters are expressed in most tissues and fulfill diverse functions. There are four human CLC channels, ClC-1, ClC-2, ClC-Ka and ClC-Kb, and five CLC transporters, ClC-3 through -7.
Gabriel eStölting +2 more
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Extracellular chloride is required for efficient platelet aggregation [PDF]
Platelets, 2018 Anion channels perform a diverse range of functions and have been implicated in ATP release, volume regulation, and phosphatidylserine exposure. Platelets have been shown to express several anion channels but their function is incompletely understood ...
Kirk A. Taylor +3 more
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Intracellular Chloride Channels: Novel Biomarkers in Diseases [PDF]
Frontiers in Physiology, 2020 Ion channels are integral membrane proteins present on the plasma membrane as well as intracellular membranes. In the human genome, there are more than 400 known genes encoding ion channel proteins.
Shubha Gururaja Rao +2 more
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