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Potent antimicrobial effect induced by disruption of chloride homeostasis
Chem, 2023© 2023 Elsevier Inc.Artificial transmembrane ion transporters have proposed applicability to medicinal chemistry, where perturbation of normal cellular homeostasis has already been shown to induce apoptosis in mammalian cells; however, this effect has not been observed in bacteria.
Brennan LE +14 more
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Altered chloride homeostasis in neurological disorders: a new target
Current Opinion in Pharmacology, 2007Other than modifying either neurotransmitter release or receptor expression and/or properties, one way to modulate gamma-aminobutyric acid (GABA)A and glycine receptor-mediated signalling is to alter the transmembrane gradient for chloride ions. Because intracellular chloride concentration is low in neurons, and the reversal potential for chloride ...
Yves De Koninck
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Chloride Homeostasis in Developing Motoneurons
2022Maturation of GABA/Glycine chloride-mediated synaptic inhibitions is crucial for the establishment of a balance between excitation and inhibition. GABA and glycine are excitatory neurotransmitters on immature neurons that exhibit elevated [Cl-]i. Later in development [Cl-]i drops leading to the occurrence of inhibitory synaptic activity. This ontogenic
Pascal, Branchereau, Daniel, Cattaert
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Hearing Research, 2011
The role of glycine and GABA as inhibitory neurotransmitters in the adult vertebrate nervous system has been well characterized in a variety of model systems, including the auditory, which is particularly well suited for analyzing inhibitory neurotransmission.
Eckhard, Friauf +3 more
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The role of glycine and GABA as inhibitory neurotransmitters in the adult vertebrate nervous system has been well characterized in a variety of model systems, including the auditory, which is particularly well suited for analyzing inhibitory neurotransmission.
Eckhard, Friauf +3 more
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Pharmacology & Therapeutics, 2020
Epilepsies represent one of the most common neurological diseases worldwide. They are characterized by recurrent spontaneous seizures with severe impact on a patient's life. An imbalance in excitatory and inhibitory signalling is considered the main underlying pathophysiological mechanism.
Auer, Theresa +3 more
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Epilepsies represent one of the most common neurological diseases worldwide. They are characterized by recurrent spontaneous seizures with severe impact on a patient's life. An imbalance in excitatory and inhibitory signalling is considered the main underlying pathophysiological mechanism.
Auer, Theresa +3 more
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ClC-2 chloride channels contribute to HTC cell volume homeostasis
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001Membrane Cl−channels play an important role in cell volume homeostasis and regulation of volume-sensitive cell transport and metabolism. Heterologous expression of ClC-2 channel cDNA leads to the appearance of swelling-activated Cl−currents, consistent with a role in cell volume regulation.
R M, Roman +5 more
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Cardiovascular Homeostasis in Rats Chronically Exposed to Mercuric Chloride
1984Two groups of male Sprague-Dawley rats received from weaning 50 micrograms/ml of mercury as mercuric chloride (HgCl2) in drinking water for 320 and 350 days. Hg exposure increased cardiac inotropism, without chronotropic changes, in both groups, and induced arterial hypertension in the rats exposed for 350 days.
CARMIGNANI, Marco, BOSCOLO P.
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Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis
Nature Neuroscience, 2009In mammals, stress elicits a stereotyped endocrine response that requires an increase in the activity of hypothalamic parvocellular neuroendocrine neurons. The output of these cells is normally constrained by powerful GABA-mediated synaptic inhibition.
Sarah A, Hewitt +3 more
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