Results 191 to 200 of about 839,045 (255)

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Early Life Inflammation Increases CA1 Pyramidal Neuron Excitability in a Sex and Age Dependent Manner through a Chloride Homeostasis Disruption. [PDF]

J Neurosci, 2019
Gomez CD, Read J, Acharjee S, Pittman QJ.   +3 more
europepmc   +1 more source

Discovery of the Cyclic Form of MRI pH‐Sensor Z‐OMPD Enables >5% 13C Hyperpolarization by SABRE

Angewandte Chemie International Edition, EarlyView.
With “c‐OMPD”, we discovered a previously unknown 5‐membered lactol structure that arises from the homoaldol condensation of the central metabolite pyruvic acid. We demonstrate that the cyclization equilibrium is of crucial importance for OMPD's function as MRI‐based pH sensor and achieve for the first time 13C polarization levels (>5%) by SABRE in the
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

Frau R, Concas L, Braccagni G, Traccis F, Branca C, Salviati S, Serra V, Corridori E, Nardi G, Pasquini G, Landi S, Santoni M, Follesa P, Brandalise F, Puligheddu M, Melis M, Ratto GM, Scheggi S, Bortolato M.   +18 more
europepmc   +1 more source

Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis. [PDF]

Kidney Int, 2017
Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Dominguez Rieg JA, Rieg T.   +5 more
europepmc   +1 more source

Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons. [PDF]

eNeuro, 2017
Sørensen AT, Ledri M, Melis M, Nikitidou Ledri L, Andersson M, Kokaia M.   +5 more
europepmc   +1 more source

Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF). [PDF]

Am J Cardiol, 2017
Grodin JL, Sun JL, Anstrom KJ, Chen HH, Starling RC, Testani JM, Tang WH.   +6 more
europepmc   +1 more source

Characterization of the extracellular matrix from human and dog umbilical cords

The Anatomical Record, EarlyView.
Abstract The extracellular matrix is important for maintaining tissue morphogenesis and homeostasis; it can also be used as a biomaterial for the production of biological scaffolds. Particularly, the umbilical cord has shown potential in the production of scaffolds for small‐diameter vessels.
Ana Carla Mendonça, Roberta Losi Guembarovski, Carlos Alberto Miqueloto, Alda Fiorina Maria Losi Guembarovski, Caio Garcia Barbosa da Silva, Laís Capelasso Lucas Pinheiro, Phelipe Oliveira Favaron   +6 more
wiley   +1 more source

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu, I. A. Anjola, L. O. Fasasi, D. P. Fadipe, A. T. Afuye, F. O. Fasanya, O. E. Oke   +6 more
wiley   +1 more source