Results 131 to 140 of about 367,155 (248)

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

open access: yesAdvanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim   +12 more
wiley   +1 more source

Discovery of 2-phenylethyl chromones as potent and selective CYP1B1 inhibitors. [PDF]

open access: yesJ Enzyme Inhib Med Chem
Chen W   +5 more
europepmc   +1 more source

Emergent Motility of Self‐Organized Particle‐Giant Unilamellar Vesicle Assembly

open access: yesAdvanced Materials, EarlyView.
Giant unilamellar vesicles (GUVs), when combined with silica particles under alternating electric fields, spontaneously self‐assemble into motile structures. Asymmetric particle decoration induces fluid flows that propel the assemblies, enabling persistent motion and reversible control.
Selcan Karaz   +5 more
wiley   +1 more source

MEP Pathway: First-Synthesized IspH-Directed Prodrugs with Potent Antimycobacterial Activity. [PDF]

open access: yesMicroorganisms
Allamand A   +5 more
europepmc   +1 more source

Rainbow Photonic Crystals: Self‐Assembly of Carbohydrate Bottlebrushes Block Copolymers

open access: yesAdvanced Materials, EarlyView.
Full‐color reflective 1D photonic crystals, capable of a tunable, responsive, and reversible color with high repeatability, are created from the self‐assembly of carbohydrate‐based brush block copolymers (BR01‐04). Abstract Tunable and responsive photonic crystal systems are the subject of great research interest owing to their ability to actively ...
Hong Li   +6 more
wiley   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

open access: yesAdvanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton   +17 more
wiley   +1 more source

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