Results 1 to 10 of about 161,699 (364)

Of chloroquine and COVID-19

Antiviral Research, 2020
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
Touret, Franck, de Lamballerie, Xavier
openaire   +5 more sources

Chloroquine is a zinc ionophore. [PDF]

PLoS ONE, 2014
Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation ...
Jing Xue, Amanda Moyer, Bing Peng, Jinchang Wu, Bethany N Hannafon, Wei-Qun Ding   +5 more
doaj   +5 more sources

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review

Frontiers in Public Health, 2020
At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway ...
Pattarawadee Prayuenyong, Pattarawadee Prayuenyong, Pattarawadee Prayuenyong, Pattarawadee Prayuenyong, Anand V. Kasbekar, Anand V. Kasbekar, Anand V. Kasbekar, David M. Baguley, David M. Baguley, David M. Baguley   +9 more
doaj   +2 more sources

Chloroquine Psychosis [PDF]

BMJ, 1966
D. B. Brookes
openalex   +3 more sources

Chloroquine Neuromyopathy [PDF]

BMJ, 1964
T. B. Begg, J. A. Simpson
openalex   +3 more sources

Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer

Cells, 2023
Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma stem
Andreas Müller, Patrick Weyerhäuser, Nancy Berte, Fitriasari Jonin, Bogdan Lyubarskyy, Bettina Sprang, Sven Rainer Kantelhardt, Gabriela Salinas, Lennart Opitz, Walter Schulz-Schaeffer, Alf Giese, Ella L. Kim   +11 more
doaj   +1 more source

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Cell Research, 2020
Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.
Manli Wang, Ruiyuan Cao, Lei-ke Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhènglì Shí, Zhìhóng Hú, Wu Zhong, Gengfu Xiao   +9 more
semanticscholar   +1 more source

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Nature Communications, 2021
Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim to estimate the effects of hydroxychloroquine
C. Axfors, A. Schmitt, P. Janiaud, J. van’t Hooft, S. Abd-Elsalam, Ehab F. Abdo, B. Abella, J. Akram, R. Amaravadi, D. Angus, Y. Arabi, Shehnoor Azhar, L. Baden, A. Baker, L. Belkhir, T. Benfield, M. Berrevoets, Cheng-Pin Chen, Tsung-Chia Chen, Shu-Hsing Cheng, Chien-Yu Cheng, W. Chung, Yehuda Z. Cohen, Lisa N. Cowan, O. Dalgard, F. F. de Almeida e Val, M. V. D. de Lacerda, G. D. de Melo, L. Derde, V. Dubée, A. Elfakir, A. Gordon, C. Hernández-Cárdenas, T. Hills, A. Hoepelman, Yi-Wen Huang, B. Igau, R. Jin, Felipe Jurado-Camacho, K. Khan, P. Kremsner, B. Kreuels, Cheng-yu Kuo, Thuy-Tien C. Le, Yi-Chun Lin, Wu-Pu Lin, Tse-Hung Lin, M. Lyngbakken, C. McArthur, B. McVerry, Patricia A Meza-Meneses, W. Monteiro, S. Morpeth, Ahmad Mourad, M. Mulligan, S. Murthy, S. Naggie, S. Narayanasamy, A. Nichol, L. Novack, Sean M. O'Brien, N. Okeke, L. Perez, R. Perez-Padilla, L. Perrin, A. Remigio-Luna, N. Rivera-Martínez, F. Rockhold, S. Rodríguez-Llamazares, R. Rolfe, Rossana Rosa, H. Røsjø, V. Sampaio, T. Seto, Muhammad Shahzad, S. Soliman, J. Stout, Ireri Thirión-Romero, A. Troxel, Ting-Yu Tseng, N. Turner, Robert J. Ulrich, S. Walsh, S. Webb, Jesper M. Weehuizen, M. Velinova, Hon-Lai Wong, R. Wrenn, F. Zampieri, Wu Zhong, D. Moher, S. N. Goodman, J. Ioannidis, L. Hemkens   +93 more
semanticscholar   +1 more source

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

BioScience Trends, 2020
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China.
Jianjun Gao, Zhenxue Tian, Xu Yang
semanticscholar   +1 more source

Neurological and psychiatric safety of tafenoquine in Plasmodium vivax relapse prevention: a review

Malaria Journal, 2020
Background Tafenoquine is an 8-aminoquinoline anti-malarial drug recently approved as a single-dose (300 mg) therapy for Plasmodium vivax relapse prevention, when co-administered with 3-days of chloroquine or other blood schizonticide. Tafenoquine 200 mg
Stephan Duparc, Stephan Chalon, Scott Miller, Naomi Richardson, Stephen Toovey   +4 more
doaj   +1 more source