Results 1 to 10 of about 125,568 (336)

Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. [PDF]

PLoS ONE, 2007
Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined.Using a ...
Rossarin Suwanarusk, Bruce Russell, Marina Chavchich, Ferryanto Chalfein, Enny Kenangalem, Varakorn Kosaisavee, Budi Prasetyorini, Kim A Piera, Marion Barends, Alan Brockman, Usa Lek-Uthai, Nicholas M Anstey, Emiliana Tjitra, François Nosten, Qin Cheng, Ric N Price   +15 more
doaj   +3 more sources

Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision) [PDF]

Ophthalmology (Rochester, Minn.), 2016
Michael F. Marmor, Ulrich Kellner, Timothy Y. Y. Lai, Ronald B. Melles, William F. Mieler   +4 more
openalex   +2 more sources

Chloroquine Overcomes Chemotherapy Resistance and Suppresses Cancer Metastasis by Eradicating Dormant Cancer Cells. [PDF]

Cell Death Dis
Mikeladze MA, Kuznetcova LS, Komarova EY, Galcheva MA, Lazarev VF, Khamaev LA, Konanova MA, Gladova YA, Danilova AB, Margulis BA, Alhasan BA, Guzhova IV.   +11 more
europepmc   +3 more sources

Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer

Cells, 2023
Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma stem
Andreas Müller, Patrick Weyerhäuser, Nancy Berte, Fitriasari Jonin, Bogdan Lyubarskyy, Bettina Sprang, Sven Rainer Kantelhardt, Gabriela Salinas, Lennart Opitz, Walter Schulz-Schaeffer, Alf Giese, Ella L. Kim   +11 more
doaj   +1 more source

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Cell Research, 2020
Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.
Manli Wang, Ruiyuan Cao, Lei-ke Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhènglì Shí, Zhìhóng Hú, Wu Zhong, Gengfu Xiao   +9 more
semanticscholar   +1 more source

Neurological and psychiatric safety of tafenoquine in Plasmodium vivax relapse prevention: a review

Malaria Journal, 2020
Background Tafenoquine is an 8-aminoquinoline anti-malarial drug recently approved as a single-dose (300 mg) therapy for Plasmodium vivax relapse prevention, when co-administered with 3-days of chloroquine or other blood schizonticide. Tafenoquine 200 mg
Stephan Duparc, Stephan Chalon, Scott Miller, Naomi Richardson, Stephen Toovey   +4 more
doaj   +1 more source

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

BioScience Trends, 2020
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China.
Jianjun Gao, Zhenxue Tian, Xu Yang
semanticscholar   +1 more source

A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. [PDF]

PLoS ONE, 2012
The predominance of chloroquine-susceptible falciparum malaria in Malawi more than a decade after chloroquine's withdrawal permits contemplation of re-introducing chloroquine for targeted uses.
Miriam K Laufer, Phillip C Thesing, Fraction K Dzinjalamala, Osward M Nyirenda, Rhoda Masonga, Matthew B Laurens, Abbie Stokes-Riner, Terrie E Taylor, Christopher V Plowe   +8 more
doaj   +1 more source

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Cell Discovery, 2020
Dear Editor, The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local economies.
Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhìhóng Hú, Wu Zhong, Manli Wang   +9 more
semanticscholar   +1 more source

Chloroquine maculopathy in a patient on long-term chloroquine therapy for pulmonary sarcoidosis: a case report

Journal of Ophthalmology, 2021
The article is on an important subject, chloroquine maculopathy associated with long-term use of chloroquine. Given that chloroquine has been widely used for the treatment of COVID-19, it is important to accumulate data on adverse reaction to chloroquine
N. V. Malachkova, T. Ie. Kozlova
doaj   +1 more source