Results 101 to 110 of about 107,140 (318)
The Affinity of Melanin for Chloroquine*
The localization of chloroquine in areas of melanin pigmentation has recently been established. Zvaifler and his co-workers (1) found that the concentration of this drug in the eyes of pigmented rats paralleled the degree of melanin pigmentation. In addition, they noted that chloroquine persists at high levels in the iris and choroid for at least 28 ...
Sams, W M, Epstein, J H
openaire +3 more sources
Hyperspectral Fluorescence Imaging with a New Polarity‐Ultrasensitive Fluorescent Probe
Based on the critical role of the π‐spacer in determining wavelength sensitivity to microenvironmental polarity, a new fluorescent probe, Lipi‐PS is rationally developed, which exhibits the highest polarity‐sensitivity so far. Its integration with hyperspectral fluorescence imaging enables multiscale polarity mapping across cells, tissues, and ...
Ri Zhou+7 more
wiley +1 more source
Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables
There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy ...
Patrick Weyerhäuser+2 more
doaj +1 more source
Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang+6 more
wiley +1 more source
Mefloquine resistant malaria in cameroon and correlation with resistance quinine
Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur+3 more
doaj +1 more source
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi+7 more
wiley +1 more source
Chloroquine Sulphate in Treatment of Chronic Discoid Lupus Erythematosus [PDF]
H. J. Lewis
openalex +1 more source
Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection
Since 2005, Chikungunya virus (CHIKV) re-emerged and caused numerous outbreaks in the world, and finally, was introduced into the Americas in 2013. The lack of CHIKV-specific therapies has led to the use of non-specific drugs.
P. Roques+10 more
semanticscholar +1 more source
Schematic representation of a PEGylated bionanocomposite facilitating the targeted delivery of Favipiravir for enhanced antiviral action against COVID. ABSTRACT This research investigates the drug delivery efficacy for 6‐fluoro‐3‐hydroxy‐2‐pyrazinecarboxamide (favipiravir) in PEGylated bionanocomposites using a predictive modeling approach.
Oluwasegun Chijioke Adekoya+4 more
wiley +1 more source
p53 is required for chloroquine-induced atheroprotection but not insulin sensitization[S]
An intact genotoxic stress response appears to be atheroprotective and insulin sensitizing. ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and ...
Babak Razani+2 more
doaj