Advanced Science, EarlyView.In bladder cancer, the overexpression of MCUB not only reduces mitochondrial calcium influx but also facilitates its binding to PRKN at Arg51, both mechanisms contribute to the impairment of PRKN‐mediated mitophagy. Consequently, the degradation of PD‐L1 is suppressed, leading to its stable expression on the tumor cell surface.
Yuan Huang +13 more
wiley +1 more source
Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias
Advanced Science, EarlyView.Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei +32 more
wiley +1 more source
Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
Advanced Science, EarlyView.FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao +8 more
wiley +1 more source
"THE EFFECT OF CHLOROQUINE ON THE INFECTIVITY OF RODENT MALARIA PARASITES TO ANOPHELES STEPHENSI " [PDF]
Iranian Journal of Public Health, 1977 There was a statistically significant difference in the number of oocysts, developed in Anopheles stephensi which had fed on mice infected with chloroquine resistant strains (NY 151./2B and. P.y.
A.N., Hamidi
doaj
Figure S5 from Chloroquine Sensitizes <i>GNAQ/11</i>-mutated Melanoma to MEK1/2 Inhibition [PDF]
, 2023 Amanda Truong +12 more
openalex +1 more source
Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex
Advanced Science, EarlyView.In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang +13 more
wiley +1 more source
Effect of Crocus sativus Stigma (saffron) alone or in combination with chloroquine on chloroquine sensitive strain of Plasmodium berghei in mice [PDF]
Journal of HerbMed Pharmacology, 2015 Introduction: In malaria treatment protocols, treatment failure or drug resistance of synthesized drugs like alkaloids related to quinine, and aminoquinolines are the main problems now.
Pestechian Nader +3 more
doaj
Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background Breast cancer remains one of the most common and lethal malignancies among women. Despite advanced targeted therapies and precision medicine, therapeutic resistance continues to undermine durable clinical responses. Increasing evidence links epigenetic dysregulation and autophagy as central contributors to breast cancer progression,
Faryal B.
europepmc +2 more sources
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source