Results 161 to 170 of about 93,237 (289)

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source

Fractional curative killing of pyronaridine or artesunate combinations with tafenoquine, 4-aminoquinolines, or azithromycin in a murine malaria-luciferase model. [PDF]

Antimicrob Agents Chemother
Lee G, Aneke JS, Sullivan DJ.
europepmc   +1 more source

Chloroquine Modulates HIV-1-Induced Plasmacytoid Dendritic Cell Alpha Interferon: Implication for T-Cell Activation

, 2009
Jeffrey Martinson, Carlos Julio Montoya, Xiomara Úsuga, Rollie Ronquillo, Alan Landay, Seema Desai   +5 more
openalex   +1 more source

Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania [PDF]

, 2020
George M. Bwire, Billy Ngasala, Wigilya P. Mikomangwa, Manase Kilonzi, Appolinary Kamuhabwa   +4 more
openalex   +1 more source

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4‐Mediated Immune Evasion in Acute Monocytic Leukaemia

Cell Proliferation, EarlyView.
Homoharringtonine (HHT) suppresses immune evasion in acute monocytic leukaemia (AML‐M5) by attenuating the FTO/m6A/LILRB4 axis, thereby enhancing CD8+ T cell cytotoxicity. ABSTRACT Acute monocytic leukaemia, a subtype of acute myeloid leukaemia (AML), is a highly aggressive malignancy characterised by a poor prognosis, primarily due to the ability of ...
Fangfang Huang, Xiang Luo, Mengyu Zhang, Le Jin, Wenxin Sun, Peihan Chen, Xiuli Hong, Chenyu Xu, Meizhi Jiang, Die Hu, Bin Zhang, Shengwei Hu, Chuanjiang Yang, Rui Gao, Jinzhang Zeng, Quanyi Lu, Qiang Luo, Jun Wu, Siming Chen   +18 more
wiley   +1 more source

Prevalence of Molecular Markers of Resistance to Antimalarial Drugs Three Years After Perennial Malaria Chemoprevention in Sierra Leone. [PDF]

Gates Open Res
Chen H, Owusu-Kyei K, Fombah AE, Williams J, García-Fernández C, Rovira-Vallbona E, Bofill A, Quintó L, Figueroa-Romero A, Mac-Abdul F, Samai M, Mayor A, Menéndez C.   +12 more
europepmc   +1 more source

The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5‐HT₃ receptors

, 2007
Andrew J. Thompson, Martin Lochner, Sarah C. R. Lummis   +2 more
openalex   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites. [PDF]

Antimicrob Agents Chemother
Mao EY, Nguyen W, Jana GP, Maity BC, Pazicky S, Giannangelo C, Reader J, Famodimu MT, Birkholtz L-M, Delves MJ, Creek DJ, Bozdech Z, Laleu B, Burrows JN, Sleebs BE, Gancheva MR, Wilson DW.   +16 more
europepmc   +1 more source

Hydroxychloroquine and Chloroquine

Clinical Infectious Diseases, 2020
openaire   +2 more sources