Results 151 to 160 of about 138,311 (269)

Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia. [PDF]

Cell Death Discov
Albuquerque de Melo M, Santos de Macedo BG, Pereira-Martins DA, Alves-Silva AB, Fonseca NP, de Miranda LBL, Silva CLA, Scheucher PS, Schuringa JJ, Machado-Neto JA, Traina F.   +10 more
europepmc   +1 more source

Boronic Acid‐Assisted Cellular Delivery of Pallado‐Fingers for Enhanced Pd(II)‐Mediated De‐Propargylation in Mammalian Cells

Chemistry–Methods, Volume 6, Issue 5, May 2026.
This study introduces “Pallado‐fingers” derived from zinc finger domain to facilitate intracellular catalysis by de‐propargylation of a dye, which was modulated by the Pd (II) co‐ligand/counterion in the order PPh3 > OAc− > Cl− which is reversed within intracellular milieu. For elevated peptide internalization, 4‐carboxyphenylboronic acid was linked to
Pritam Ghosh
wiley   +1 more source

Captivating Synergistic, Dose-Dependent Anticancer Effects of Tumor-Regulation Modulators Chloroquine and Ivermectin Completely Abolished by an Opposing Modulator, Deoxycholic Acid, in Hamster Fibrosarcoma: In Vivo, In Vitro, and Literature Review. [PDF]

Pharmaceuticals (Basel)
Popović KJ, Popović DJ, Miljković D, Popović JK, Poša M, Drljača Lero J, Dolićanin Z.   +6 more
europepmc   +1 more source

Citrate‐Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Background Abnormal accumulation of lipids within the kidney contributes to the progression of chronic kidney disease, but the underlying metabolic mechanisms remain unclear. Citrate is a central metabolite in cellular energy regulation and is frequently elevated in advanced kidney disease, yet its impact on renal lipid metabolism has not been
Marta Sanz‐Gómez, Beatriz Linillos‐Pradillo, Rubén Fernández de la Rosa, Isabel Aránguez, Reinhold Kreutz, Antonia García, Coral Barbas, Adrián Plaza, María S. Fernández‐Alfonso   +8 more
wiley   +1 more source

Social inequalities in the misbelief of chloroquine's protective effect against COVID-19: results from the EPICOVID-19 study in Brazil. [PDF]

PLoS One
Nunes BP, Crochemore-Silva I, Mielke GI, Vidaletti LP, Mesenburg MA, da Silveira MF, Hallal PC.   +6 more
europepmc   +1 more source

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Gabriela K. Borges, Gabriella B. Das Neves, Letícia Reichardt, Ubirajara Maciel da Costa, Luiz C. Miletti, Amanda L. Bastos‐Pereira   +5 more
wiley   +1 more source

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, Volume 183, Issue 9, Page 1901-1919, May 2026.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Correction: Chloroquine overcomes chemotherapy resistance and suppresses cancer metastasis by eradicating dormant cancer cells. [PDF]

Cell Death Dis
Mikeladze MA, Kuznetcova LS, Komarova EY, Galcheva MA, Lazarev VF, Khamaev LA, Konanova MA, Gladova YA, Danilova AB, Margulis BA, Alhasan BA, Guzhova IV.   +11 more
europepmc   +1 more source

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2826-2842, May 2026.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

Uptake of Nanoparticles as a Model System for Viruses under the Presence of Chloroquine. [PDF]

ACS Nanosci Au
Chen G, Zhu D, Zhao Y, Soh TK, Wang R, Feliu N, Parak WJ.   +6 more
europepmc   +1 more source