Results 181 to 190 of about 125,568 (336)

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

UHPLC/MS Profile and Antimalarial Potency of <i>Enantia chlorantha</i> Oliv. (Annonaceae) Stem Bark Aqueous Extract. [PDF]

Adv Pharmacol Pharm Sci
Messi Betene AN, Gounoue Kamkumo R, Tsouh Fokou PV, Ngueguim Tsofack F, Mbock MA, Madiesse Kemgne EA, Ngako A, Ngwem Tenlep LS, Tsakem Nangap MJ, Fokou R, Dize D, Owona P, Tchatat Tali MB, Fekam Boyom F, Dimo T.   +14 more
europepmc   +1 more source

The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis. [PDF]

, 1995
JC Wetsteyn, PJ De Vries, B. Oosterhuis, CJ Van Boxtel   +3 more
openalex   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Comparative molecular surveillance of polymorphisms in chloroquine resistance transporter, multidrug resistance 1, and Kelch 13 genes associated with antimalarial drug resistance in Plasmodium falciparum isolates from Western Kenya. [PDF]

Malar J
Bungei J, Ouma C, Zhong D, Oyweri J, Lee MC, Zhou G, Atieli H, Githure J, Wang C, Yan G.   +9 more
europepmc   +1 more source

Tricks in Plasmodium’s molecular repertoire – Escaping 3′UTR excision-based conditional silencing of the chloroquine resistance transporter gene

, 2012
Andrea Ecker, Rebecca E. Lewis, Eric H. Ekland, Bamini Jayabalasingham, David A. Fidock   +4 more
openalex   +2 more sources

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

The contrasting effects of two antimalarial drugs on insulin secretion. [PDF]

Cell Mol Life Sci
Lu J, Xiong F, Zhang Q, Zhao R, Zhang C, Wei G, Yang J.   +6 more
europepmc   +1 more source

Pathological pigmentation of the skin and palate caused by continuous use of chloroquine

, 2017
Kívia Linhares Ferrazzo, Márcia Rodrigues Payeras, Patrícia Surkamp, Cristiane Cademartori Danesi   +3 more
openalex   +1 more source

Malaria Screening and Treatment in Hematopoietic Cell Transplant Donors and Sickle Cell Disease Candidates/Recipients: A Case Series Using Malaria Polymerase Chain Reaction Testing and a Literature Review

Transplant Infectious Disease, EarlyView.
Malaria polymerase chain reaction (PCR) testing is more sensitive than conventional diagnostics. Routine PCR screening of at‐risk asymptomatic hematopoietic cell donors and transplant candidates may prevent unnecessary deferrals or treatment. In our experience, PCR negativity during screening or after treatment supports donor/candidate eligibility ...
Mary M. Czech, Sanchita Das, Emily Limerick, Courtney Fitzhugh, Matthew Hsieh, Jennifer Cuellar‐Rodriguez   +5 more
wiley   +1 more source