Results 191 to 200 of about 107,140 (318)
Anticancer Potential of Myricetin against Huh7- and Hep3B-Derived Liver Cancer Stem Cells through the Regulation of Apoptosis, Autophagy, and Stemness. [PDF]
Kwon M, Jung HJ.
europepmc +1 more source
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang+11 more
wiley +1 more source
Chloroquine or hydroxychloroquine for prophylaxis of COVID-19
N. Principi, S. Esposito
semanticscholar +1 more source
EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi+12 more
wiley +1 more source
The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway. [PDF]
Xu D+11 more
europepmc +1 more source
Inoculum effect with chloroquine and Plasmodium falciparum [PDF]
Ilya Y. Gluzman+2 more
openalex +1 more source
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim+6 more
wiley +1 more source