Results 191 to 200 of about 107,140 (318)

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang   +11 more
wiley   +1 more source

Chloroquine or hydroxychloroquine for prophylaxis of COVID-19

open access: yesLancet. Infectious Diseases (Print), 2020
N. Principi, S. Esposito
semanticscholar   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi   +12 more
wiley   +1 more source

The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway. [PDF]

open access: yesDiscov Oncol
Xu D   +11 more
europepmc   +1 more source

Inoculum effect with chloroquine and Plasmodium falciparum [PDF]

open access: green, 1987
Ilya Y. Gluzman   +2 more
openalex   +1 more source

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim   +6 more
wiley   +1 more source

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