Results 201 to 210 of about 107,140 (318)

Interconnections of insulin/IGF‐1 signaling and autophagy abnormalities in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Impaired insulin (INS) and insulin‐like growth factor 1 (IGF‐1) signaling are features of both brain aging and late‐onset Alzheimer's disease (LOAD). However, their exact underlying mechanisms and cause‐and‐effect linkages, including the downstream regulation of endocytosis and autophagy, are still not well understood.
Wang Liao   +13 more
wiley   +1 more source

Personalised Medicine in Cervical Cancer: Evaluating Therapy Resistance Through Multi‐Model Approaches

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Introduction Cervical cancer remains a leading cause of malignancy among women globally, disproportionately affecting women from low‐to‐middle‐income countries, including South Africa. The high prevalence in impoverished communities places significant pressure on the public healthcare system.
Madré Meyer   +9 more
wiley   +1 more source

A Case Report of Generalization of Localized Actinic Granuloma, an Unusual Diffuse Presentation Not Responding to Tofacitinib

open access: yesClinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Actinic granuloma (AG), a rare and idiopathic skin condition primarily affecting middle‐aged and elderly individuals, is known for its persistent, asymptomatic annular plaques appearing on sun‐exposed areas. This report details the case of a 48‐year‐old diabetic male farmer with a rare presentation of generalized AG. The patient's lesions were
Saman Al‐Zahawi   +2 more
wiley   +1 more source

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