Results 201 to 210 of about 93,237 (289)

Changes in the Prevalence of Antimalarial Partner Drug Resistance Markers and Policy in 6 Sub-Saharan African Countries From 2000 to 2021: A Systematic Review. [PDF]

Open Forum Infect Dis
Walker A, Ross A, Nsanzabana C.
europepmc   +1 more source

Supplementary Figure S7 from Combined Vorinostat and Chloroquine Inhibit Sodium–Iodide Symporter Endocytosis and Enhance Radionuclide Uptake <i>In Vivo</i>

Martin L. Read, Katie Brookes, Ling Zha, Selvambigai Manivannan, Jana Kim, Merve Kocbiyik, Alice Fletcher, Caroline M. Gorvin, George Firth, Gilbert O. Fruhwirth, Juan P. Nicola, Sissy Jhiang, Matthew D. Ringel, Moray J. Campbell, Kavitha Sunassee, Philip J. Blower, Kristien Boelaert, Hannah R. Nieto, Vicki E. Smith, Christopher J. McCabe   +19 more
openalex   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Targeted Sequencing Identifies SNPs Associated with Antimalarial Drug Resistance and the CSP Vaccine Antigen in <i>Plasmodium falciparum</i> from Southwest Cameroon. [PDF]

Int J Mol Sci
Efeti MT, Fankem SN, Diallo MT, Lahngong MS, Acha NL, Shey RA, Demeyer K, Souopgui J, Ghogomu SM, Njemini R.   +9 more
europepmc   +1 more source

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, Volume 12, Issue 45, December 4, 2025.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

Computational insights into harmala alkaloids as novel antimalarial candidates against Plasmodium falciparum. [PDF]

Sci Rep
Dipto KZ, Shariar R, Saha CK, Huzaifa A, Robin TB, Patil RB, Alam MT, Rafi MIH, Faruk MAZ, Moin AT, Zinnah KMA, Hasanuzzaman M, Islam T.   +12 more
europepmc   +1 more source

Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression

Advanced Science, Volume 12, Issue 46, December 11, 2025.
CD19‐293‐EV can switch the CD19 endocytosis pathway from clathrin‐mediated endocytosis to aggregation‐dependent endocytosis, leading to lysosomal degradation of the CD19/EVs complex. Degradation of the EVs leads to impairment in the IFN response and enhancement in EV uptake by target cells, creating a potent feedback cycle.
Zixuan Huang, Chaoqun Lu, Yixin Wang, Huajian Xian, Yuling Zheng, Ting Kang, Rufang Xiang, Shufeng Xie, Minghui Wang, Zeyi Li, Xiaoli Xia, Yaoyifu Yu, Wenjie Zhang, Huijian Zheng, Renyao Pan, Dan Li, Chunjun Zhao, Han Liu   +17 more
wiley   +1 more source

Antimalarial activity of root extract of Tephrosia villosa L. Pers. (Fabaceae) on Plasmodium berghei-infected mice. [PDF]

Sci Rep
Alemu MA, Moges TA, Ketsela Zeleke T, Abebe RB, Zewdu WS.   +4 more
europepmc   +1 more source

Proteomic analysis links truncated tau to lysosome motility, autophagy, and endo‐lysosomal dysfunction

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Tauopathies involve progressive accumulation of abnormal tau species that disrupt the autophagy‐lysosomal pathway (ALP), critical for degrading intracellular macromolecules and aggregates, leading to toxicity and cell death. This study examines how overexpression of the N‐terminally truncated Tau35 protein affects proteolytic ...
Despoina Goniotaki, Maximilian Hausherr, Steven Lynham, Ayushin Ale, George Chennell, Stefania Marcotti, Katrin Marcus, Wendy Noble, Diane P. Hanger, Graham Fraser, Deepak P. Srivastava   +10 more
wiley   +1 more source

Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A. [PDF]

Commun Chem
McBride CM, McCauley M, Harris NR, Amin S, Curtis BJ, Verhey-Henke L, Teklemichael AA, Oliphant EN, Dranchak P, Lev KL, Qu F, Snodgrass HM, Lewis JC, Inglese J, Su XZ, Pereira F, Sherman DH.   +16 more
europepmc   +1 more source