Results 201 to 210 of about 125,568 (336)

Pinellia pedatisecta Schott‐Derived Exosome‐Like Nanovesicles Promote Apoptosis in Colorectal Cancer by Regulating the Lysosome‐Mediated Mitophagy Pathway

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Pinellia pedatisecta Schott‐derived exosome‐like nanovesicles (PPS‐ELNs) are efficiently taken up by colorectal cancer (CRC) cells and exhibit tumor‐targeting properties. Mechanistically, PPS‐ELNs suppress tumor progression by inhibiting the proliferation of CRC cells and promoting apoptosis through regulation of the lysosome‐mediated mitophagy pathway.
Pingsheng Zhou, Qingling Zhang, Xiaotao Zhou, Ge Zhang, Shiping Cheng   +4 more
wiley   +1 more source

RCC1 Domain‐Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy‐Dependent WNT5A Secretion in Cancer‐Associated Fibroblasts

Journal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
RCCD1 is upregulated in colon cancer and cancer‐associated fibroblasts (CAFs). In CAFs, RCCD1 overexpression activates AMPK/mTOR/ULK1 signaling, enhancing autophagy. This stimulates autophagic secretion of WNT5A. WNT5A then activates the nonclassical Wnt/CaMKII/ERK pathway in tumor cells, promoting epithelial‐mesenchymal transition (EMT), proliferation,
Chao Liu, Sheng Xu, Yuanyuan Liu, Yuntian Tang   +3 more
wiley   +1 more source

Chloroquine Enhances Mitochondrial Antiviral Signaling-Mediated Cytokine Induction and Alters Mitochondrial Morphology. [PDF]

J Innate Immun
Kao YT, Chen WS, Shie CT, Yu CY.
europepmc   +1 more source

Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology [PDF]

, 2016
Paul S. Callaghan, Amila Siriwardana, Matthew R. Hassett, Paul D. Roepe   +3 more
openalex   +1 more source

Safety profile of chloroquine and hydroxychloroquine: a disproportionality analysis of the FDA Adverse Event Reporting System database.

, 2021
Georgios Papazisis, Spyridon Siafis, D. Cepatyte, Dimitrios Giannis, Εleni Stamoula, Dimitrios Tzachanis, Toine C. G. Egberts   +6 more
openalex   +2 more sources

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

Guillain-Barré Syndrome Following Malaria: A Rare Case Report From Rural Ethiopia and Literature Review. [PDF]

Clin Case Rep
Abdela HA, Kimo NH, Woyimo TG.
europepmc   +1 more source

Comparative Cardiac Effects of Chlorproguanil/Dapsone and Chloroquine During Treatment of Acute Uncomplicated Falciparum Malaria Infection in Nigerian Children [PDF]

, 2011
O. O. Ogunkunle, Fatai A. Fehintola, T O Ogungbamigbe, Catherine O. Falade   +3 more
openalex  

Reduced Proteasome Degradation of HSF‐1 Shifts Protein Stress Management With Age in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 2, February 2026.
Ageing C. elegans prioritises chronic protein stress protection over acute stress response by coordinating HSF‐1 activity. Decreased PBS‐7 binding in aged worms reduces HSF‐1 degradation, enhancing its ability to upregulate protective factors against accumulating protein aggregates while simultaneously suppressing its activation under acute heat shock.
Hongwei Wang, Fengzhen Sun, Zhidong He, Xiaojie Wang, Hao Liu, Mengjiao Song, Qingxia Chen, Zhixue Li, Ligang Wu, Xiumin Yan, Xueliang Zhu, Yidong Shen   +11 more
wiley   +1 more source

Molecular epidemiology of Plasmodium falciparum drug resistance and vaccine targets in high-transmission settings in Africa. [PDF]

Sci Rep
Aliyu IA, Bala JA, Musa BM, Amole TG, Ahmed AB, Kovalenko G, Umar A, Garba Y, Gwarzo SA, Mansur A, Hidaya MG, Aliyu MH, Galadanci HS.   +12 more
europepmc   +1 more source