Results 31 to 40 of about 93,237 (289)

The mechanism of chloroquine/hydroxychloroquine and its application in stomatological diseases

口腔疾病防治, 2021
Chloroquine and hydroxychloroquine are both classic 4-aminoquinoline antimalarial drugs with similar chemical structures and mechanisms of action.
LIN Lin, WU Kaihui, WANG Wenmei
doaj   +1 more source

Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Chloroquine (CQ) is highly effective against P. vivax, due to the rapid spread of CQ resistance in P. falciparum parasites; it is no longer the drug of choice against P. falciparum. This study elucidates the scenario of chloroquine efficacy at times that
Sabyasachi Das, Satyajit Tripathy, Sourav Chattopadhayay, Balaram Das, Santanu Kar Mahapatra, Amiya Kumar Hati, Somenath Roy   +6 more
doaj   +1 more source

Effect of chloroquine on Candida albicans biofilms and its drug resistance [PDF]

Kouqiang yixue
Objective To evaluate the effects of chloroquine alone and in combination with traditional antifungal agents on the Candida albicans biofilms and its drug resistance.
WU Qiaochu, SHI Banruo, MIAO Haochen, WEI Xin
doaj   +1 more source

No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.

PLoS ONE, 2021
BackgroundChloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events.
Josefine Beck-Friis, Susannah Leach, Elmir Omerovic, Rickard Zeijlon, Magnus Gisslen, Aylin Yilmaz   +5 more
doaj   +1 more source

Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model

Frontiers in Pharmacology, 2022
Chloroquine was once thought to be a promising treatment for COVID-19 but it quickly failed due to its inefficiency and association with increased mortality. Further, comorbidities such as hypertension may have contributed this failure.
Junqi Wang, Junqi Wang, Xian Jing, Xian Jing, Lizhong Hua, Yuling Zheng, Yuling Zheng, Shiheng Hu, Shiheng Hu, Jing Xiao, Jing Xiao, Dawei Guo, Dawei Guo, Wenda Wu, Wenda Wu, Hui Ji, Hui Ji, Lin Peng, Lin Peng, Shanxiang Jiang, Shanxiang Jiang, Xiuge Gao, Xiuge Gao   +22 more
doaj   +1 more source

Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis

Cellular Physiology and Biochemistry, 2017
Background/Aims: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on ...
Feng Wang, Jinyuan Tang, Pengchao Li, Shuhui Si, Hao Yu, Xiao Yang, Jun Tao, Qiang Lv, Min Gu, Haiwei Yang, Zengjun Wang   +10 more
doaj   +1 more source

Long cryopreserved lab-adapted Plasmodium falciparum increases resistance to chloroquine but not its susceptibility

Life Sciences, Medicine and Biomedicine, 2020
Introduction: Plasmodium falciparum (P. falciparum) is a deadly protozoan that is accountable for malaria and chloroquine was the first-line antimalarial drug before its withdrawal and replaced by artemisinin.
Jing Yit Pua, Nurhidanatasha Abu Bakar, Nik Abdul Aziz Nik Kamarudin, Siti Zulaiha Ghazali, Khairul Mohd Fadzli Mustaffa   +4 more
doaj   +1 more source

Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance

Malaria Journal, 2009
Background The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported ...
Linhardt Robert J, Zhang Zhenqing, Solakyildirim Kemal, Bhattacharyya Sumit, Tobacman Joanne K   +4 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Chloroquine Inhibits Ca2+ Signaling in Murine CD4+ Thymocytes

Cellular Physiology and Biochemistry, 2015
Background/Aims: Bitter-tasting chloroquine can suppress T cell activation by inhibiting Ca2+ signaling. However, the mechanism of inhibition remains largely unclear.
Jin-Chao Xu, Yong-Bo Peng, Ming-Yu Wei, Yi-Fan Wu, Donglin Guo, Gangjian Qin, Guangju Ji, Jinhua Shen, Qing-Hua Liu   +8 more
doaj   +1 more source