Results 31 to 40 of about 125,568 (336)

The mechanism of chloroquine/hydroxychloroquine and its application in stomatological diseases

口腔疾病防治, 2021
Chloroquine and hydroxychloroquine are both classic 4-aminoquinoline antimalarial drugs with similar chemical structures and mechanisms of action.
LIN Lin, WU Kaihui, WANG Wenmei
doaj   +1 more source

Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19

Cochrane Database of Systematic Reviews, 2020
Background The coronavirus disease 2019 (COVID‐19) pandemic has resulted in substantial mortality. Some specialists proposed chloroquine (CQ) and hydroxychloroquine (HCQ) for treating or preventing the disease. The efficacy and safety of these drugs have
Bhagteshwar Singh, H. Ryan, T. Kredo, Marty Chaplin, T. Fletcher   +4 more
semanticscholar   +1 more source

Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea

Malaria Journal, 2018
Background Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuation has been reported in dozens ...
Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje, Toshihiro Mita   +10 more
doaj   +1 more source

Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19)

Open Forum Infectious Diseases, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents ...
K. Pastick, E. Okafor, Fan Wang, S. Lofgren, C. Skipper, M. Nicol, M. Pullen, R. Rajasingham, E. McDonald, T. Lee, Ilan S. Schwartz, L. Kelly, S. Lother, O. Mitjà, E. Letang, M. Abassi, D. Boulware   +16 more
semanticscholar   +1 more source

Effect of chloroquine on Candida albicans biofilms and its drug resistance [PDF]

Kouqiang yixue
Objective To evaluate the effects of chloroquine alone and in combination with traditional antifungal agents on the Candida albicans biofilms and its drug resistance.
WU Qiaochu, SHI Banruo, MIAO Haochen, WEI Xin
doaj   +1 more source

Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Chloroquine (CQ) is highly effective against P. vivax, due to the rapid spread of CQ resistance in P. falciparum parasites; it is no longer the drug of choice against P. falciparum. This study elucidates the scenario of chloroquine efficacy at times that
Sabyasachi Das, Satyajit Tripathy, Sourav Chattopadhayay, Balaram Das, Santanu Kar Mahapatra, Amiya Kumar Hati, Somenath Roy   +6 more
doaj   +1 more source

No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.

PLoS ONE, 2021
BackgroundChloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events.
Josefine Beck-Friis, Susannah Leach, Elmir Omerovic, Rickard Zeijlon, Magnus Gisslen, Aylin Yilmaz   +5 more
doaj   +1 more source

Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection

Canadian Medical Association Journal, 2020
KEY POINTS Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly around the globe in recent months. With deaths from its associated disease, coronavirus disease 2019 (COVID-19), projected to reach into the millions and a vaccine
D. Juurlink
semanticscholar   +1 more source

Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis

Cellular Physiology and Biochemistry, 2017
Background/Aims: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on ...
Feng Wang, Jinyuan Tang, Pengchao Li, Shuhui Si, Hao Yu, Xiao Yang, Jun Tao, Qiang Lv, Min Gu, Haiwei Yang, Zengjun Wang   +10 more
doaj   +1 more source

Long cryopreserved lab-adapted Plasmodium falciparum increases resistance to chloroquine but not its susceptibility

Life Sciences, Medicine and Biomedicine, 2020
Introduction: Plasmodium falciparum (P. falciparum) is a deadly protozoan that is accountable for malaria and chloroquine was the first-line antimalarial drug before its withdrawal and replaced by artemisinin.
Jing Yit Pua, Nurhidanatasha Abu Bakar, Nik Abdul Aziz Nik Kamarudin, Siti Zulaiha Ghazali, Khairul Mohd Fadzli Mustaffa   +4 more
doaj   +1 more source