Results 41 to 50 of about 125,568 (336)

Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance

Malaria Journal, 2009
Background The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported ...
Linhardt Robert J, Zhang Zhenqing, Solakyildirim Kemal, Bhattacharyya Sumit, Tobacman Joanne K   +4 more
doaj   +1 more source

Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model

Frontiers in Pharmacology, 2022
Chloroquine was once thought to be a promising treatment for COVID-19 but it quickly failed due to its inefficiency and association with increased mortality. Further, comorbidities such as hypertension may have contributed this failure.
Junqi Wang, Junqi Wang, Xian Jing, Xian Jing, Lizhong Hua, Yuling Zheng, Yuling Zheng, Shiheng Hu, Shiheng Hu, Jing Xiao, Jing Xiao, Dawei Guo, Dawei Guo, Wenda Wu, Wenda Wu, Hui Ji, Hui Ji, Lin Peng, Lin Peng, Shanxiang Jiang, Shanxiang Jiang, Xiuge Gao, Xiuge Gao   +22 more
doaj   +1 more source

Chloroquine Attenuates Oxidative Stress in Gentamicin-Induced Nephrotoxicity in Rats

Dose-Response, 2022
The wider application of gentamicin is limited by potential adverse effects (nephrotoxicity and ototoxicity). The goal of our study was to investigate the effects of chloroquine on biochemical and oxidative stress parameters in gentamicin-induced ...
Branislava Medić Brkić, Branislav Rovčanin, Marko Stojanović, Dragana Srebro, Sonja Vučković, Katarina Savić Vujović   +5 more
doaj   +1 more source

A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease‐19 (COVID‐19)

International Journal of Rheumatic Diseases, 2020
The pandemic coronavirus disease‐19 (COVID‐19) has pushed the global healthcare system to a crisis and amounted to a huge economic burden. Different drugs for prophylaxis against COVID‐19 including chloroquine (CQ) or hydroxychloroquine (HCQ) have been ...
Sanket Shah, S. Das, Avinash Jain, D. Misra, V. Negi   +4 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Chloroquine Inhibits Ca2+ Signaling in Murine CD4+ Thymocytes

Cellular Physiology and Biochemistry, 2015
Background/Aims: Bitter-tasting chloroquine can suppress T cell activation by inhibiting Ca2+ signaling. However, the mechanism of inhibition remains largely unclear.
Jin-Chao Xu, Yong-Bo Peng, Ming-Yu Wei, Yi-Fan Wu, Donglin Guo, Gangjian Qin, Guangju Ji, Jinhua Shen, Qing-Hua Liu   +8 more
doaj   +1 more source

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

medRxiv, 2020
Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro.
Mingxing Huang, Man Li, Fei Xiao, P. Pang, Jiabi Liang, T. Tang, Shaoxuan Liu, Binghui Chen, Jingxian Shu, Yingying You, Yang Li, Meiwen Tang, Jianhui Zhou, Guanmin Jiang, J. Xiang, Wen-xin Hong, Songmei He, Zhaoqin Wang, Jianhua Feng, Changqing Lin, Y. Ye, Zhi-long Wu, Yaocai Li, Bei Zhong, Ruilin Sun, Z. Hong, Jing Liu, Huili Chen, Xiaohua Wang, Zhonghe Li, D. Pei, Lin Tian, J. Xia, Shanping Jiang, Nanshan Zhong, H. Shan   +35 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei [PDF]

Iranian Journal of Parasitology, 2008
Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent Plasmodia.
N Ghobakhloo, M Nateghpour, S Rezaee, H Hajjaran, M Mohebali, H Abedkhojasteh   +5 more
doaj   +1 more source

p53 is required for chloroquine-induced atheroprotection but not insulin sensitization[S]

Journal of Lipid Research, 2010
An intact genotoxic stress response appears to be atheroprotective and insulin sensitizing. ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and ...
Babak Razani, Chu Feng, Clay F. Semenkovich   +2 more
doaj   +1 more source