Acute effect of prednisolone on renal handling of sodium. [PDF]
, 1973 The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB).
Halgrimson, CG +3 more
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Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability [PDF]
, 2013 YesIn order to investigate the effect of using different solid state forms and specific surface area (TBET) of active pharmaceutical ingredients on tabletability and dissolution performance, the mono- and dihydrated crystalline forms of ...
Abdul Jaleel O. W. +30 more
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FGF23 regulates renal sodium handling and blood pressure
EMBO Molecular Medicine, 2014 Fibroblast growth factor‐23 (FGF23) is a bone‐derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na+:Cl− co‐transporter NCC ...
Olena Andrukhova +7 more
doaj +1 more source
Generic sample preparation combined with high-resolution liquid chromatography- time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories [PDF]
, 2010 A unification of doping-control screening procedures of prohibited small molecule substances—including stimulants, narcotics, steroids, ß2-agonists and diuretics—is highly urgent in order to free resources for new classes such as banned proteins ...
Georgakopoulos, C.G. +4 more
core +3 more sources
The principles underlying the use of powder diffraction data in solving pharmaceutical crystal structures [PDF]
, 2013 Solving pharmaceutical crystal structures from powder diffraction data is discussed in terms of the methodologies that have been applied and the complexity of the structures that have been solved.
Edgeley, David S. +4 more
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Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system [PDF]
, 2012 YesObjectives This work investigated the impact of spray drying variables such as feedconcentration, solvent composition and the drying mode, on the micromeriticproperties of chlorothiazide sodium (CTZNa) and chlorothiazide potassium(CTZK).Methods ...
Amaro +25 more
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Kidney & Blood Pressure Research, 2018 Background/Aims: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient’s awareness and ...
David Spirk +5 more
doaj +1 more source
Co-crystal structures of furosemide:urea and carbamazepine:indomethacin determined from powder x-ray diffraction data [PDF]
, 2020 Co-crystallization is a promising approach to improving both the solubility and the dissolution rate of active pharmaceutical ingredients. Crystal structure determination from powder diffraction data plays an important role in determining co-crystal ...
Al Rahal, Okba +4 more
core +2 more sources
A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability [PDF]
, 2012 YesHigh-dose API powders which are to be tableted by direct compression should have high compactibility and compressibility. This note reports on a novel approach to the manufacture of crystalline powders intended for direct compaction with improved ...
Adamczyk, B. +4 more
core +1 more source