Results 21 to 30 of about 5,213 (178)
BMC Chemistry, 2023 Designing new, verified methodologies with a focus on sustainability, analytical efficiency, simplicity, and the environment has become a major priority for pharmaceutical quality control units.
Hoda M. Marzouk +3 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2011 – Purpose. Oral drug administration remains the most common and most convenient way used in clinical therapy. The availability of a simple, rapid, economic and reproducible in vitro method to assess drug absorption is a very helpful tool.
Mohamed Ali Lassoued +2 more
doaj +1 more source
BMC Chemistry, 2023 Cardiovascular disorders are among the leading causes of death worldwide, especially hypertension, a silent killer syndrome requiring multiple drug therapy for appropriate management.
Hoda M. Marzouk +5 more
doaj +1 more source
ABCG2 modulates chlorothiazide permeability in vitro – characterization of the interaction [PDF]
, 2012 We are showing that chlorothiazide, a diuretic, is an ABCG2 substrate. It is a Biopharmaceutics Classification System/Biopharmaceutics Drug Distribution and Classification System (BCS/BDDCS) Class IV drug with low bioavailability.
Kis Emese +12 more
core +1 more source
FGF23 regulates renal sodium handling and blood pressure
EMBO Molecular Medicine, 2014 Fibroblast growth factor‐23 (FGF23) is a bone‐derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na+:Cl− co‐transporter NCC ...
Olena Andrukhova +7 more
doaj +1 more source
Transdifferentiation of Integrin Beta 1 High+ Skin Progenitor Cells Into Functional Hepatocytes. [PDF]
Stem Cells IntA highly reproducible and functional liver model that closely resembles the human liver plays a crucial role in drug development, disease research, personalized medicine, and regenerative medicine. This study aimed to establish an in vitro liver model using skin epidermal progenitor cells (EPCs), which are easily accessible and exhibit a high ...
Lim JH, Kim DH, Lee J, Jung CR, Kang HM.
europepmc +2 more sources
Chlorothiazide N,N-dimethylacetamidedisolvate
, 2007 Chlorothiazide forms a 1:2 solvate with N,N-dimethylacetamide (systematic name: 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N,N-dimethylacetamide disolvate), C7H6ClN3O4S2·2C4H9NO. The compound crystallizes with one chlorothiazide and two
Johnston, Andrea +3 more
core +1 more source
Chlorothiazide dimethyl sulfoxide solvate
, 2007 Chlorothiazide forms a 1:1 solvate with dimethyl sulfoxide (systematic name: 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide dimethyl sulfoxide solvate), C7H6ClN3O4S2·C2H6OS.
Johnston, Andrea +3 more
core +1 more source
Kidney & Blood Pressure Research, 2018 Background/Aims: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient’s awareness and ...
David Spirk +5 more
doaj +1 more source