FGF23 regulates renal sodium handling and blood pressure
EMBO Molecular Medicine, 2014 Fibroblast growth factor‐23 (FGF23) is a bone‐derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na+:Cl− co‐transporter NCC ...
Olena Andrukhova +7 more
doaj +1 more source
Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials [PDF]
, 2012 YesObjectives In this work we investigated the residual organic solvent content and physicochemical properties of spray-dried chlorothiazide sodium (CTZNa) and potassium (CTZK) salts.
Al-Obaidi +28 more
core +1 more source
Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses [PDF]
, 2013 BACKGROUND: Hypertension has been cited as the most common attributable risk factor for death worldwide, and in Canada more than one of every five adults had this diagnosis in 2007.
Andrea Tricco +12 more
core +1 more source
Kidney & Blood Pressure Research, 2018 Background/Aims: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient’s awareness and ...
David Spirk +5 more
doaj +1 more source
The principles underlying the use of powder diffraction data in solving pharmaceutical crystal structures [PDF]
, 2013 Solving pharmaceutical crystal structures from powder diffraction data is discussed in terms of the methodologies that have been applied and the complexity of the structures that have been solved.
Edgeley, David S. +4 more
core +1 more source
Co-crystal structures of furosemide:urea and carbamazepine:indomethacin determined from powder x-ray diffraction data [PDF]
, 2020 Co-crystallization is a promising approach to improving both the solubility and the dissolution rate of active pharmaceutical ingredients. Crystal structure determination from powder diffraction data plays an important role in determining co-crystal ...
Al Rahal, Okba +4 more
core +2 more sources
A Comprehensive Cocrystal Screening Study of Chlorothiazide
, 2017 This work was supported by Science Foundation Ireland under Grant No. 12/RC/2275 as part of the Synthesis and Solid State Pharmaceutical Centre (SSPC). M.A. acknowledges the Royal Embassy of Saudi Arabia for a Saudi Arabia Government Scholarship.
Marwah Aljohani +3 more
semanticscholar +1 more source
Hospital Pharmacy, 2018 Background: Thiazide diuretics are often utilized to overcome loop diuretic resistance when treating acute decompensated heart failure (ADHF). In addition to a large cost advantage, several pharmacokinetic advantages exist when administering oral ...
Brian C. Bohn +3 more
semanticscholar +1 more source
Micro-RNAS that control myosin expression and myofiber identity [PDF]
, 2015 The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber
Olson, Eric N., van Rooij, Eva
core +1 more source
A monoclinic polymorph of chlorothiazide
Acta Crystallographica Section E: Crystallographic CommunicationsA new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than ...
Rowan K. H. Brydson, Alan R. Kennedy
doaj +1 more source