Results 11 to 20 of about 54,869 (285)

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

mBio, 2020
Efflux pumps of the resistance nodulation-cell division (RND) superfamily are major contributors to multidrug resistance for most of the Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii ...
E. Grimsey, Chiara Fais, Robert L. Marshall, V. Ricci, M. Ciusa, Jack W. Stone, A. Ivens, G. Malloci, P. Ruggerone, A. Vargiu, L. Piddock   +10 more
semanticscholar   +1 more source

Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19

Clinical drug investigation, 2020
Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID-19) on the grounds of its potential antiviral and anti-inflammatory effects.
N. Hoertel, M. Sánchez Rico, R. Vernet, A. Jannot, A. Neuraz, C. Blanco, C. Lemogne, G. Airagnes, N. Paris, C. Daniel, Alexandre Gramfort, G. Lemaître, M. Bernaux, A. Bellamine, N. Beeker, F. Limosin   +15 more
semanticscholar   +1 more source

The Effects of Chlorpromazine on Reproductive System and Function in Female Rats [PDF]

International Journal of Fertility and Sterility, 2015
Background Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth ...
Zahra Zamani, Samad Zare, Rajabali Sadrkhanlou, Abbas Ahmadi, Elham Movahed   +4 more
doaj   +1 more source

Dynamic Changes in Plasma Metabolic Profiles Reveal a Potential Metabolite Panel for Interpretation of Fatal Intoxication by Chlorpromazine or Olanzapine in Mice

Metabolites, 2022
Diagnosing the cause of fatal intoxication by antipsychotic agents is an important task in forensic practice. In the 2020 Annual Report of the American Association of Poison Control Centers, among 40 deaths caused by antipsychotics, 21 cases were ...
Rui Bai, Xiaohui Dai, Xingang Miao, Bing Xie, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +7 more
doaj   +1 more source

Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps

Journal of experimental & clinical cancer research : CR, 2020
Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgical resection followed by radiotherapy plus ...
C. Abbruzzese, S. Matteoni, M. Persico, V. Villani, M. G. Paggi   +4 more
semanticscholar   +1 more source

A single blind comparative clinical study of the effects of chlorpromazine and risperidone on positive and negative symptoms in patients of schizophrenia

Indian Journal of Psychological Medicine, 2011
Objectives: The present study was undertaken to test the comparative efficacy of chlorpromazine and risperidone in patients of schizophrenia in a tertiary care hospital of Maharashtra.
Amrita Prakash Singam, Abhishek Mamarde, Prakash B Behere   +2 more
doaj   +1 more source

Quetiapine Ameliorates MIA-Induced Impairment of Sensorimotor Gating: Focus on Neuron-Microglia Communication and the Inflammatory Response in the Frontal Cortex of Adult Offspring of Wistar Rats

Cells, 2022
The maternal immune activation produced by the systemic administration of lipopolysaccharide (LPS) in rats provides valuable insights into the basis of behavioural schizophrenia-like disturbances and biochemical changes in the brains of the offspring ...
Katarzyna Chamera, Katarzyna Curzytek, Kinga Kamińska, Ewa Trojan, Agnieszka Basta-Kaim   +4 more
doaj   +1 more source

Efficacy and safety of chlorpromazine as an adjuvant therapy for glioblastoma in patients with unmethylated MGMT gene promoter: RACTAC, a phase II multicenter trial

Frontiers in Oncology, 2023
IntroductionDrug repurposing is a promising strategy to develop new treatments for glioblastoma. In this phase II clinical trial, we evaluated the addition of chlorpromazine to temozolomide in the adjuvant phase of the standard first-line therapeutic ...
Andrea Pace, Giuseppe Lombardi, Veronica Villani, Dario Benincasa, Claudia Abbruzzese, Ilaria Cestonaro, Martina Corrà, Marta Padovan, Giulia Cerretti, Mario Caccese, Antonio Silvani, Paola Gaviani, Diana Giannarelli, Gennaro Ciliberto, Marco G. Paggi   +14 more
doaj   +1 more source

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Medicina, 2019
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery.
Jeand Baloch, M. Sohail, Hafiz Sarwar, M. H. Kiani, G. Khan, S. Jahan, M. Rafay, M. T. Chaudhry, M. Yasinzai, G. Shahnaz   +9 more
semanticscholar   +1 more source

The polarographic determination of chlorpromazine and chlorpromazine sulphoxide

Journal of Pharmacy and Pharmacology, 1966
Abstract Cathodic polarography of solutions containing between 0·1 and 5·0 μg/ml of both chlorpromazine and its sulphoxide enables the sulphoxide to be determined directly. Reductive polarography of the solution after bromination gives an additive wave from which the chlorpromazine is determined by subtraction.
Jean Beresford, G. S. Porter
openaire   +3 more sources