Results 11 to 20 of about 79,424 (330)

Chlorpromazine versus placebo for schizophrenia [PDF]

open access: yesCochrane Database of Systematic Reviews, 2014
BACKGROUND Chlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia. OBJECTIVES To review the effects of chlorpromazine compared with placebo, for the treatment of schizophrenia.
Abrams   +486 more
core   +2 more sources

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro

open access: yesFrontiers in Oncology, 2021
The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
S. Matteoni   +9 more
semanticscholar   +1 more source

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

open access: yesmBio, 2020
Efflux pumps of the resistance nodulation-cell division (RND) superfamily are major contributors to multidrug resistance for most of the Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii ...
E. Grimsey   +10 more
semanticscholar   +1 more source

Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19

open access: yesClinical drug investigation, 2020
Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID-19) on the grounds of its potential antiviral and anti-inflammatory effects.
N. Hoertel   +15 more
semanticscholar   +1 more source

Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps

open access: yesJournal of experimental & clinical cancer research : CR, 2020
Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgical resection followed by radiotherapy plus ...
C. Abbruzzese   +4 more
semanticscholar   +1 more source

A dual dopaminergic therapy with L-3,4-dihydroxyphenylalanine and chlorpromazine for the treatment of blepharospasm, a focal dystonia: Possible implications for striosomal D1 signaling

open access: yesFrontiers in Neurology, 2022
Impairment of balanced activity between dopamine D1 and D2 receptor functions in the striatum, particularly in striatal functional subdivisions (i.e., striosome and matrix compartments), has been proposed to underlie dystonia genesis.
Shinichi Matsumoto   +6 more
doaj   +1 more source

Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]

open access: yes, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T   +11 more
core   +1 more source

Agmatine prevents acute chlorpromazine-induced neurotoxicity in rats [PDF]

open access: yesArhiv za farmaciju, 2015
The present study was directed to potentially beneficial effects of agmatine (AGM) on oxidative/nitrosative stress development in selective vulnerable brain regions during chlorpromazine (HPZ) treatment in rats.
Dejanović Bratislav   +5 more
doaj   +1 more source

Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles

open access: yesMolecules, 2023
Nasal drug delivery has been a focus of scientific interest for decades. A number of drug delivery systems and devices are available and have been highly successful in providing better and more comfortable therapy. The benefits of nasal drug delivery are
Thinh To Quoc   +12 more
doaj   +1 more source

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

open access: yesPharmaceutics, 2022
Chlorpromazine (CPZ) is an antipsychotic drug which can cause several adverse effects and drug poisoning. Recent studies demonstrated that CPZ forms highly stable complexes with certain cyclodextrins (CDs) such as sulfobutylether-β-CD (SBECD) and ...
Eszter Fliszár-Nyúl   +4 more
doaj   +1 more source

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