Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes. [PDF]
British medical journal, 1978 Richard David Leslie, David A. Pyke
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Formulation development of immediate release chlorpropamide tablets using directly compressible excipients [PDF]
, 2014 Diabetes mellitus is a major cause of morbidity and mortality worldwide. Chlorpropamide is an oral antidiabetic drug belonging to sulphonyl urea group, frequently prescribed in the treatment of type II diabetes mellitus.
Khuram Shahzad Ahmad +9 more
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Study of structural response of chlorpropamide polymorphs to external stress [PDF]
, 2014 Alisa I. Ivanenko +6 more
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, 2016 Three polymorphs of tolbutamide (IL, II, and III) were studied using single-crystal X-ray diffraction, from 100 K to room temperature (forms II and III) and to 350 K (form I), and differential scanning calorimetry. The reversible transformation, IL ⇔ IH,
T.N. Drebushchak +3 more
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Roux-en-Y gastric bypass surgery decreases intestinal aryl hydrocarbon receptor signaling in male mice. [PDF]
Physiol RepAbstract The impact of Roux‐en‐Y gastric bypass (RYGB) on indole metabolism and AhR signaling is poorly understood. Therefore, we tested the hypothesis that RYGB changes the indole metabolite profile in the gut, leading to changes in AhR signaling. To test this hypothesis, we developed a mouse model of RYGB that recapitulates the human procedure. Given
Wang A +4 more
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Association between insulin resistance and prostate volume: A 4-year analysis from the Reduction by Dutasteride of Prostate Cancer (REDUCE) Trial. [PDF]
BJUI CompassAbstract Objectives Most, but not all studies, suggest insulin resistance is associated with benign prostatic hyperplasia, but its impact on prostate volume (PV) changes over time remains unclear. We examined whether higher insulin resistance, measured by Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR), is associated with larger PV and ...
Daniels JP +6 more
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Spatial and Temporal Visualization of Polymorphic Transformations in Pharmaceutical Tablets. [PDF]
Angew Chem Int Ed EnglX‐ray Diffraction Computed Tomography (XRD‐CT) has been used to reveal pressure‐induced phase transformations in pharmaceutical tablets of glycolide as a function of compaction pressure. Temporal analysis of the tablets, and subsequent identification using electron diffraction, revealed a hydrolysis reaction occurred on storage of the tablets.
Gasol-Cardona J +9 more
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Autoimmune Complications of Lymphoproliferative Diseases. [PDF]
Hematol OncolABSTRACT Peripheral autoimmune cytopenias may complicate a fraction of lymphoproliferative disorders (LPD), particularly chronic lymphocytic leukemia, non‐Hodgkin B‐cell lymphomas, angioimmunoblastic T‐cell lymphoma and large granular lymphocytic leukemia.
Barcellini W, Fattizzo B.
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Halogen Bonding in Sulphonamide Co-Crystals: X···π Preferred over X···O/N?
Molecules, 2023 Sulphonamides have been one of the major pharmaceutical compound classes since their introduction in the 1930s. Co-crystallisation of sulphonamides with halogen bonding (XB) might lead to a new class of pharmaceutical-relevant co-crystals. We present the
Tobias Heinen +3 more
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Simultaneous Quantification of Antidiabetic Agents in Human Plasma by a UPLC-QToF-MS Method. [PDF]
PLoS ONE, 2016 An ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the simultaneous quantification of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and ...
Mariana Millan Fachi +4 more
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