Results 11 to 20 of about 331,698 (221)

Low‐Carbohydrate Diet Exacerbates Denervation‐Induced Atrophy of Rat Skeletal Muscle Under the Condition of Identical Protein Intake [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background While decreased protein intake is associated with muscle mass loss, it is unclear whether a decrease in carbohydrate intake adversely affects muscle atrophy independently of protein intake.
Aki Yokogawa, Kohei Kido, Ikuru Miura, Eisuke Oyama, Daisuke Takakura, Keigo Tanaka, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Kentaro Kawanaka   +9 more
doaj   +2 more sources

Process development for Trastuzumab production from Chinese Hamster Ovary (CHO) in laboratory scale

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2022
Background: CHO cells have been commonly used in the production of recombinant protein. It is reported that around 70% recombinant therapeutic proteins are produced in CHO cells systems and the market size exceed 15£ billion per year.
Nguyễn Quang Huy, Từ Tiểu My, Hứa Hoàng Quốc Huy, Nguyễn Trường An, Hà Tấn Phát, Nguyễn Thị Thùy Trang, Đinh Văn Long, Trịnh Thanh Hùng, Đỗ Minh Sĩ   +8 more
doaj   +1 more source

Mitochondrial membrane potential-enriched CHO host: a novel and powerful tool for improving biomanufacturing capability

mAbs, 2022
With the aim of increasing protein productivity of Chinese hamster ovary (CHO) cells, we sought to generate new CHO hosts with favorable biomanufacturing phenotypes and improved functionality.
Lina Chakrabarti, Raghothama Chaerkady, Junmin Wang, Shao Huan Samuel Weng, Chunlei Wang, Chen Qian, Lisa Cazares, Sonja Hess, Peter Amaya, Jie Zhu, Diane Hatton   +10 more
doaj   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Strategy for Developing a Stable CHO Cell Line that Produces Large Titers of Trastuzumab Antibody

Frontiers in Bioscience-Elite, 2023
Background: Trastuzumab (Herceptin®) is currently the main treatment option for breast cancer patients that overexpress the human epidermal growth factor receptor 2 (HER2). This antibody binds specifically to HER2, blocks cancer cell growth, and promotes
Hafsa Boulenouar, Nadia Bouchoutrouch, Youssef Amar, Moulay El Abbes Faouzi, Yahia Cherrah, Hassan Sefrioui, Hassan Ait Benhassou   +6 more
doaj   +1 more source

Proton Magnetic Resonance Spectroscopy at 3.0T in Rabbit With VX2 Liver Cancer: Diagnostic Efficacy and Correlations With Tumor Size

Frontiers in Oncology, 2022
PurposesThe purpose of this study was to explore the diagnostic performance of Cho peak area (Cho Are), Cho peak amplitude (Cho Amp), and the combined approach (Cho Are_Amp) in detecting rabbit VX2 liver cancer at the early stage via hydrogen-1 proton ...
Ruikun Liao, Ruikun Liao, Zhuoyue Tang, Zhuoyue Tang, Xiaojiao Li, Xiaojiao Li, Liang Lv, Chao Yang, Chao Yang, Hua Xiong, Hua Xiong, Bi Zhou, Bi Zhou, Jiayi Yu, Jiayi Yu, Dan Zhang, Dan Zhang   +16 more
doaj   +1 more source

β-Hydroxybutyrate Oxidation in Exercise Is Impaired by Low-Carbohydrate and High-Fat Availability

Frontiers in Medicine, 2021
Purpose: In this study, we determined ketone oxidation rates in athletes under metabolic conditions of high and low carbohydrate (CHO) and fat availability.Methods: Six healthy male athletes completed 1 h of bicycle ergometer exercise at 75% maximal ...
David J. Dearlove, David Holdsworth, Tom Kirk, Leanne Hodson, Evelina Charidemou, Eline Kvalheim, Brianna Stubbs, Andrew Beevers, Julian L. Griffin, Rhys Evans, Jeremy Robertson, Kieran Clarke, Pete J. Cox   +12 more
doaj   +1 more source

Pengaruh Pemberian Minuman Karbohidrat (Maltodekstrin 12,5%) Praoperasi terhadap Kejadian Mual dan Muntah Pascamastektomi

Jurnal Anestesi Perioperatif, 2020
Mual dan muntah pascaoperasi (postoperative nausea and vomiting, PONV) menjadi masalah yang umum terjadi setelah operasi mastektomi dengan angka kejadian berkisar 21–92%.
Andre Aditya, Iwan Fuadi, Iwan Abdul Rachman   +2 more
doaj   +1 more source

Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility

Membranes, 2021
In the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility.
Yifan Liu, Zhengqi Liu, Ya Gao, Weiwei Gao, Zhaosheng Hou, Yuzheng Zhu   +5 more
doaj   +1 more source

Effects of carbohydrate and protein supplement strategies on endurance capacity and muscle damage of endurance runners: A double blind, controlled crossover trial

Journal of the International Society of Sports Nutrition, 2022
Background The purpose of this study is to explore the effect of carbohydrate only or carbohydrate plus protein supplementation on endurance capacity and muscle damage.
Yiheng Liang, Yan Chen, Fan Yang, Jørgen Jensen, Ruirui Gao, Longyan Yi, Junqiang Qiu   +6 more
doaj   +1 more source