Results 111 to 120 of about 11,449,307 (399)

Enhancing the Antibody Production Efficiency of Chinese Hamster Ovary Cells through Improvement of Disulfide Bond Folding Ability and Apoptosis Resistance

open access: yesCells
The complex structure of monoclonal antibodies (mAbs) expressed in Chinese hamster ovary (CHO) cells may result in the accumulation of unfolded proteins, triggering endoplasmic reticulum (ER) stress and an unfolded protein response (UPR).
Chen Zhang   +7 more
doaj   +1 more source

Standardized network reconstruction of CHO cell metabolism [PDF]

open access: yesarXiv, 2013
We have created a genome-scale network reconstruction of chinese hamster ovary (CHO) cell metabolism. Existing reconstructions were improved in terms of annotation standards, to facilitate their subsequent use in dynamic modelling. The resultant network is available from ChoNet (http://cho.sf.net/).
arxiv  

Conditional Handover Modelling for Increased Contention Free Resource Use in 5G-Advanced [PDF]

open access: yesarXiv, 2023
This paper elaborates on Conditional Handover (CHO) modelling, aimed at maximizing the use of contention free random access (CFRA) during mobility. This is a desirable behavior as CFRA increases the chance of fast and successful handover. In CHO this may be especially challenging as the time between the preparation and the actual cell change can be ...
arxiv  

Stratum Corneum‐Inspired Zwitterionic Hydrogels with Intrinsic Water Retention and Anti‐Freezing Properties for Intelligent Flexible Sensors

open access: yesAdvanced Functional Materials, EarlyView.
A novel stratum corneum‐inspired zwitterionic hydrogel is developed for intelligent, flexible sensors, featuring intrinsic water retention and anti‐freezing properties. The quasi‐gel, composed of hygroscopic polymers and bound water, maintains its softness across a wide range of humidity.
Meng Wu   +8 more
wiley   +1 more source

Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

open access: yesBiotechnology and Bioengineering, 2014
Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry as a host for the production of complex pharmaceutical proteins. Thus genome engineering of CHO cells for improved product quality and yield is of great interest.
Carlotta Ronda   +6 more
semanticscholar   +2 more sources

Mini-Column for Cytoadherence: A New Method for Measuring the Relative Size of Binding Subpopulations in Plasmodium falciparum Isolates [PDF]

open access: yesIranian Journal of Parasitology, 2011
Background: Cytoadherence of Plasmodium falciparum- infected red blood cells to endothelial cells is an important mechanism for parasite survival and a major trigger for diseases pathology.
N Kalantari, S Ghaffari
doaj   +1 more source

Control of Ferromagnetism of Vanadium Oxide Thin Films by Oxidation States

open access: yesAdvanced Functional Materials, EarlyView.
The nonstoichiometric VOx exhibits a distinct ferromagnetic hysteresis loop and demonstrates a high magnetic susceptibility (χ=dMdH$ = \frac{{dM}}{{dH}}\;$∼10). Micromagnetic simulations show the results of the “partial volume fraction ferromagnetic phase model” for VOx/Co/Pt structure.
Kwonjin Park   +9 more
wiley   +1 more source

Optimization of Heavy Chain and Light Chain Signal Peptides for High Level Expression of Therapeutic Antibodies in CHO Cells

open access: yesPLoS ONE, 2015
Translocation of a nascent protein from the cytosol into the ER mediated by its signal peptide is a critical step in protein secretion. The aim of this work was to develop a platform technology to optimize the signal peptides for high level production of
Ryan Haryadi   +10 more
semanticscholar   +1 more source

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

open access: yesJournal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi   +5 more
doaj  

Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells [PDF]

open access: yes, 2018
Misfolded proteins are recognized by the protein quality control and eventually degraded by the ubiquitin-proteasome system. Previously, we demonstrated accumulation of a misfolded non-glycosylated protein, namely proinsulin, in enlarged pre-Golgi ...
Fan, Jing-Yu   +2 more
core  

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