Results 41 to 50 of about 12,852,402 (297)
Optimization of human interferon beta protein expression in Chinese hamster ovary cells [PDF]
Journal of Shahrekord University of Medical Sciences, 2021 Background and aims: Human interferon beta-1a (hIFNβ-1a) is a 22.5-kDa glycoprotein used to treat diseases such as multiple sclerosis (MS). Because of appropriate post-translation modifications, protein isolation, and lack of toxicity in Chinese hamster ...
Nasrin Xodadadi +3 more
doaj +1 more source
The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]
, 2015 Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia +4 more
core +1 more source
The emerging role of systems biology for engineering protein production in CHO cells.
Current Opinion in Biotechnology, 2018 To meet the ever-growing demand for effective, safe, and affordable protein therapeutics, decades of intense efforts have aimed to maximize the quantity and quality of recombinant proteins produced in CHO cells.
Chih-Chung Kuo +5 more
semanticscholar +1 more source
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
, 2008 Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
core +3 more sources
CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells [PDF]
Metabolic Engineering, 2023 Chinese hamster ovary (CHO) cells are extensively used for the production of glycoprotein therapeutics proteins, for which N-linked glycans are a critical quality attribute due to their influence on activity and immunogenicity. Manipulation of protein glycosylation is commonly achieved through cell or process engineering, which are often guided by ...
Kotidis, Pavlos +11 more
openaire +5 more sources
Scientific Reports, 2017 Chinese hamster ovary (CHO) cells are the most common cell line used for the production of therapeutic proteins including monoclonal antibodies (mAbs). Host cell proteins (HCPs), secreted and released from lysed cells, accumulate extracellularly during ...
Jin Hyoung Park +5 more
semanticscholar +1 more source
PLoS ONE, 2012 Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells.
Gaëlle Gonzalez +5 more
doaj +1 more source
High Throughput miRNA Screening Identifies miR-574-3p Hyperproductive Effect in CHO Cells
Biomolecules, 2021 CHO is the cell line of choice for the manufacturing of many complex biotherapeutics. The constant upgrading of cell productivity is needed to meet the growing demand for these life-saving drugs.
Živa Švab +7 more
doaj +1 more source
Awakening dormant glycosyltransferases in CHO cells with CRISPRa
Biotechnology and Bioengineering, 2019 Chinese hamster ovary (CHO) cells are the preferred workhorse for the biopharmaceutical industry, and CRISPR/Cas9 has proven powerful for generating targeted gene perturbations in CHO cells.
Karen Julie la Cour Karottki +11 more
semanticscholar +1 more source
Cell surface glycoproteins of CHO cells
Experimental Cell Research, 1986 Experimental Cell Research 165 (1986) 92-106. doi:10.1016/0014-4827(86)90535-5 ; Received by publisher: 1985-10-29 ; Harvest Date: 2016-01-04 12:19:39 ; DOI:10.1016/0014-4827(86)90535-5 ; Page Range: 92 ...
Thomas J. Raub, R.Michael Roberts
openaire +2 more sources