Results 51 to 60 of about 4,711,608 (247)

Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Frontiers in Bioengineering and Biotechnology, 2022
Recombinant therapeutic proteins (RTPs) are important parts of biopharmaceuticals. Chinese hamster ovary cells (CHO) have become the main cell hosts for the production of most RTPs approved for marketing because of their high-density suspension growth ...
Zheng-Mei Li, Zheng-Mei Li, Zhen-Lin Fan, Zhen-Lin Fan, Xiao-Yin Wang, Xiao-Yin Wang, Tian-Yun Wang, Tian-Yun Wang   +7 more
doaj   +1 more source

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells [PDF]

, 2015
Iron overload coupled with low hepcidin levels are characteristics of hereditary haemochromatosis. To understand the role of transferrin receptor (TFR) and intracellular iron in hepcidin secretion, Chinese hamster ovary transferrin receptor variant (CHO ...
Garcia, M, Greenwell, P., Mehta, Kosha, Greenwell, Pamela, Busbridge, Mark, Mehta, K., Busbridge, M, Renshaw, Derek, Mehta, K, Patel, VB, Farnaud, Sebastien; id_orcid, Greenwell, P, Renshaw, Derek; id_orcid, Garcia, Mitla, Renshaw, D, Farnaud, Sebastien, Patel, Vinood B., Farnaud, S., Patel, Vinood B, Patel, V. B., Renshaw, D., Farnaud, S, Mehta, Kosha; id_orcid   +22 more
core   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Mini-Column for Cytoadherence: A New Method for Measuring the Relative Size of Binding Subpopulations in Plasmodium falciparum Isolates [PDF]

Iranian Journal of Parasitology, 2011
Background: Cytoadherence of Plasmodium falciparum- infected red blood cells to endothelial cells is an important mechanism for parasite survival and a major trigger for diseases pathology.
N Kalantari, S Ghaffari
doaj   +1 more source

Multimode Oxide‐Based Optoelectronic Memtransistor for In‐Sensor Vision Processing

Advanced Functional Materials, EarlyView.
A multimode optoelectronic memtransistor (OEMT) is demonstrated for vision explainable artificial intelligence (VXAI) hardware. By integrating optical sensing, electrical masking, and non‐volatile memory, the device enables key operations required for generating saliency information.
Min Gu Lee, Geunyoung Kim, Hwa Young Kim, Do Hoon Kim, Hanchan Song, Huisu Noh, Jungwan Noh, Seungwoo Lee, Sang‐Hee Ko Park, Himchan Cho, Kyung Min Kim   +10 more
wiley   +1 more source

Functionalizing Micro‐to‐Mesoscopic Electrode Architectures for Regulating Electron Transfer Behaviors in Electrocatalysis

Advanced Functional Materials, EarlyView.
A systematic review is conducted to assess the influence of electrode architecture across micro‐ to mesoscopic length scales on electron‐transfer pathways in electrocatalysis. We discuss the structure‐activity relationships in electrocatalytic applications, including resource recovery and environmental remediation, and provide cost‐effective, efficient
Manshu Zhao, Jiaojiao Zhang, Shideng Yuan, Xinmeng Yu, Keming Wan, Xiaoguang Duan, Zhining Wang   +6 more
wiley   +1 more source

Editorial: On the cusp of rational CHO cell engineering [PDF]

Biotechnology Journal, 2015
With the emergence of additional data on genomic variants, a more detailed molecular understanding of cellular processes and enhanced capabilities in fine-tuned manipulation of cell behaviour, the coming years promise to be exciting game changers in the production of therapeutics in mammalian cells.
Nielsen, Lars, Borth, Nicole
openaire   +4 more sources

Balancing Hydrophobicity and Hydrophilicity: Dual Filler‐Engineered Proton Exchange Membranes for Durable, High‐Power Fuel Cells

Advanced Functional Materials, EarlyView.
Polarity‐matched Zr–MOFs program Nafion's nanoscale morphology during solution casting. Hydrophilic UiO‐66 preserves hydrated pathways, while hydrophobic UiO‐67 increases the proton hopping sites by densifying ionic clusters. Combining both fillers yields a membrane that delivers 176 mS cm−1 conductivity, reaches 1.46 W cm−2 under 200 kPa, and triples ...
Yonghwi Cho, Yunseong Ji, Minkyu Choi, Junsu Kim, Yejin Kim, Su Jeong Lee, Wooyoung Choi, Choong Hoo Lee, Ju Yeon Kim, Ohchan Kwon, Hanim Kim, Du Yeol Ryu, Ki Chul Kim, Dae Woo Kim   +13 more
wiley   +1 more source

Enhancing the Antibody Production Efficiency of Chinese Hamster Ovary Cells through Improvement of Disulfide Bond Folding Ability and Apoptosis Resistance

Cells
The complex structure of monoclonal antibodies (mAbs) expressed in Chinese hamster ovary (CHO) cells may result in the accumulation of unfolded proteins, triggering endoplasmic reticulum (ER) stress and an unfolded protein response (UPR).
Chen Zhang, Yunhui Fu, Wenyun Zheng, Feng Chang, Yue Shen, Jinping Niu, Yangmin Wang, Xingyuan Ma   +7 more
doaj   +1 more source

PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO

OncoImmunology, 2017
Immunotherapy with anti-GD2 antibody (Ab) ch14.18/CHO is effective for treatment of high-risk neuroblastoma (NB) patients and is mainly based on GD2-specific Ab-dependent cellular cytotoxicity (ADCC).
Nikolai Siebert, Maxi Zumpe, Madlen Jüttner, Sascha Troschke-Meurer, Holger N. Lode   +4 more
doaj   +1 more source