Results 21 to 30 of about 89,075 (280)

Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand

Frontiers in Public Health, 2022
Distal cholangiocarcinoma (dCCA) is a rare type of CCA in Asia, even in Opisthorchis viverrini-prevalent Northeastern Thailand. The clinical ambiguity and imprecision of diagnosis surrounding this malignancy result in high mortality due often to advanced/
Waritta Kunprom, Waritta Kunprom, Waritta Kunprom, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Piyapharom Intarawichian, Piyapharom Intarawichian, Walailak Bamrungkit, Walailak Bamrungkit, Walailak Bamrungkit, Malinee Thanee, Malinee Thanee, Malinee Thanee, Piya Prajumwongs, Piya Prajumwongs, Piya Prajumwongs, Watcharin Loilome, Watcharin Loilome, Watcharin Loilome, Narong Khuntikeo, Narong Khuntikeo, Narong Khuntikeo, Attapol Titapun, Attapol Titapun, Attapol Titapun, Apiwat Jareanrat, Apiwat Jareanrat, Apiwat Jareanrat, Vasin Thanasukarn, Vasin Thanasukarn, Vasin Thanasukarn, Tharatip Srisuk, Tharatip Srisuk, Tharatip Srisuk, Vor Luvira, Vor Luvira, Vor Luvira, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Julaluck Promsorn, Julaluck Promsorn, Julaluck Promsorn, Supinda Koonmee, Supinda Koonmee, Supinda Koonmee   +53 more
doaj   +1 more source

Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models

Cancer & Metabolism, 2021
Background Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no effective chemotherapy.
Malinee Thanee, Sureerat Padthaisong, Manida Suksawat, Hasaya Dokduang, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Arporn Wangwiwatsin, Prakasit Sa-ngiamwibool, Narong Khuntikeo, Hideyuki Saya, Watcharin Loilome   +12 more
doaj   +1 more source

Single-cell transcriptomic analysis suggests two molecularly distinct subtypes of intrahepatic cholangiocarcinoma

Nature Communications, 2022
Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment. Here, by performing single-cell RNA sequencing on 144,878 cells from 14 pairs of iCCA tumors and non ...
Guohe Song, Yang Shi, Lu Meng, Jiaqiang Ma, Siyuan Huang, Juan Zhang, Yingcheng Wu, Jiaxin Li, Youpei Lin, Shuaixi Yang, D. Rao, Yifei Cheng, Jian Lin, S. Ji, Yuming Liu, Shan Jiang, Xiaoliang Wang, Shu Zhang, A. Ke, Xiaoying Wang, Yanlong Cao, Yuan Ji, Jian Zhou, Jia Fan, Xiaoming Zhang, Ruibin Xi, Q. Gao   +26 more
semanticscholar   +1 more source

Metabolic Phenotyping Predicts Gemcitabine and Cisplatin Chemosensitivity in Patients With Cholangiocarcinoma

Frontiers in Public Health, 2022
Gemcitabine and cisplatin serve as appropriate treatments for patients with cholangiocarcinoma (CCA). Our previous study using histoculture drug response assay (HDRA), demonstrated individual response patterns to gemcitabine and cisplatin.
Manida Suksawat, Manida Suksawat, Manida Suksawat, Jutarop Phetcharaburanin, Jutarop Phetcharaburanin, Jutarop Phetcharaburanin, Jutarop Phetcharaburanin, Poramate Klanrit, Poramate Klanrit, Poramate Klanrit, Nisana Namwat, Nisana Namwat, Nisana Namwat, Narong Khuntikeo, Narong Khuntikeo, Narong Khuntikeo, Attapon Titapun, Attapon Titapun, Attapon Titapun, Apiwat Jarearnrat, Apiwat Jarearnrat, Apiwat Jarearnrat, Vanlakhone Vilayhong, Vanlakhone Vilayhong, Vanlakhone Vilayhong, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Anchalee Techasen, Anchalee Techasen, Anchalee Techasen, Arporn Wangwiwatsin, Arporn Wangwiwatsin, Arporn Wangwiwatsin, Arporn Wangwiwatsin, Panupong Mahalapbutr, Panupong Mahalapbutr, Jia V. Li, Watcharin Loilome, Watcharin Loilome, Watcharin Loilome, Watcharin Loilome   +41 more
doaj   +1 more source

Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway

Cancer Gene Therapy, 2023
Cholangiocarcinoma is a highly aggressive malignant tumor disease with the increasing incidence and mortality. It’s urgent to identify specific biomarkers for cholangiocarcinoma treatment and diagnosis. Recent studies have noted the importance of lncRNAs
Qingfeng Ni, Hai Zhang, Xiaoli Shi, Xiangcheng Li   +3 more
semanticscholar   +1 more source

The role of tumor-infiltrating lymphocytes in cholangiocarcinoma

Journal of experimental & clinical cancer research : CR, 2022
Cholangiocarcinoma (CCA) is the second most common primary liver cancer and associated with a dismal prognosis due to the lack of an efficient systemic therapy. In contrast to other cancers, new immunotherapies have demonstrated unsatisfactory results in
Dong Liu, L. Heij, Z. Czigany, E. Dahl, S. Lang, T. Ulmer, Tom Luedde, U. Neumann, J. Bednarsch   +8 more
semanticscholar   +1 more source

Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein

Integrative Cancer Therapies, 2022
Owing to the crucial role of Src in cancer metastasis, interruption of Src and its signaling has been considered a promising strategy for cancer metastasis treatment.
Putthaporn Kaewmeesri MS, Piman Pocasap PhD, Veerapol Kukongviriyapan PhD, Auemduan Prawan PhD, Sarinya Kongpetch PhD, Laddawan Senggunprai PhD   +5 more
doaj   +1 more source

Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression

Frontiers in Pharmacology, 2021
An aberrant regulation of lipid metabolism is involved in the pathogenesis and progression of cancer. Up-regulation of lipid biosynthesis enzymes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN) and HMG-CoA reductase (HMGCR), has been ...
Jittima Tomacha, Jittima Tomacha, Hasaya Dokduang, Sureerat Padthaisong, Nisana Namwat, Nisana Namwat, Poramate Klanrit, Poramate Klanrit, Jutarop Phetcharaburanin, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Arporn Wangwiwatsin, Tueanjit Khampitak, Supinda Koonmee, Supinda Koonmee, Attapol Titapun, Attapol Titapun, Apiwat Jarearnrat, Apiwat Jarearnrat, Narong Khuntikeo, Narong Khuntikeo, Watcharin Loilome, Watcharin Loilome   +22 more
doaj   +1 more source

EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma.

Cancer Discovery, 2022
FGFR inhibitors are approved for the treatment of advanced cholangiocarcinoma harboring FGFR2 fusions. However, the response rate is moderate, and resistance emerges rapidly due to acquired secondary FGFR2 mutations or due to other less-defined ...
Qibiao Wu, Yuanli Zhen, Lei Shi, P. Vu, Patricia Greninger, Ramzi Adil, J. Merritt, Regina K. Egan, Meng-Ju Wu, Xunqin Yin, Cristina R. Ferrone, V. Deshpande, I. Baiev, C. Pinto, D. McLoughlin, C. Walmsley, James R. Stone, J. Gordan, A. Zhu, D. Juric, L. Goyal, C. Benes, N. Bardeesy   +22 more
semanticscholar   +1 more source

Survival after surgery among patients with cholangiocarcinoma in Northeast Thailand according to anatomical and morphological classification

BMC Cancer, 2021
Background Cholangiocarcinoma (CCA) has been categorized based on tumor location as intrahepatic (ICCA), perihilar (PCCA) or distal (DCCA), and based on the morphology of the tumor of the bile duct as mass forming (MF), periductal infiltrating (PI) or ...
Chaiwat Tawarungruang, Narong Khuntikeo, Nittaya Chamadol, Vallop Laopaiboon, Jaruwan Thuanman, Kavin Thinkhamrop, Matthew Kelly, Bandit Thinkhamrop   +7 more
doaj   +1 more source