Results 31 to 40 of about 89,075 (280)

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma

Hepatology, 2021
Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are increasingly well characterized, but their impact on outcome and prognosis remains unknown.
T. Boerner, E. Drill, L. Pak, Bastien Nguyen, C. Sigel, A. Doussot, P. Shin, D. Goldman, M. Gonen, P. Allen, V. Balachandran, A. Cercek, J. Harding, D. Solit, N. Schultz, Ritika Kundra, H. Walch, M. D'Angelica, R. DeMatteo, J. Drebin, N. Kemeny, T. Kingham, Amber L. Simpson, J. Hechtman, E. Vakiani, M. Lowery, J. Ijzermans, S. Buettner, B. Koerkamp, M. Doukas, R. Chandwani, W. Jarnagin   +31 more
semanticscholar   +1 more source

Curcumin-loaded nanocomplexes alleviate the progression of fluke-related cholangiocarcinoma in hamsters

Cancer Nanotechnology, 2023
Background Curcumin-loaded nanocomplexes (CNCs) previously demonstrated lower toxicity and extended release better than is the case for free curcumin. Here, we evaluated the efficacy of CNCs against opisthorchiasis-associated cholangiocarcinoma (CCA) in ...
Chanakan Jantawong, Yaovalux Chamgramol, Kitti Intuyod, Aroonsri Priprem, Chawalit Pairojkul, Sirinapha Klungsaeng, Rungtiwa Dangtakot, Thatsanapong Pongking, Chutima Sitthirach, Porntip Pinlaor, Sakda Waraasawapati, Somchai Pinlaor   +11 more
doaj   +1 more source

Cholangiocarcinoma: Epidemiology and risk factors

Liver international (Print), 2019
Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction between host‐specific genetic background and multiple risk factors.
Shahid A. Khan, S. Tavolari, G. Brandi
semanticscholar   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma

Annals of Hepatology, 2016
Background and aim. Trophoblast cell surface antigen 2 (TROP2) or tumor-associated calcium signal transducer 2 (TACSTD2) is a 36-kDa type I transmembrane glycoprotein and exerts dual functions as an oncogene and tumor suppressor in cancer cells.
Kanlayanee Sawanyawisuth, Ph.D., Nattawat Tantapotinan, Ratthaphol Kraiklang, Anucha Puapairoj, Chaisiri Wongkham, Gregory J. Riggins, Sopit Wongkham   +6 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Preclinical studies of toxicity and anti-cholangiocarcinoma activity of the standardized capsule formulation of Atractylodes lancea (Thunb.) DC

BMC Complementary Medicine and Therapies, 2023
Background Cholangiocarcinoma (CCA), the adenocarcinoma of the biliary duct, is commonly reported in Asia, with the highest incidence in northeastern Thailand. Chemotherapy of CCA has been limited by the lack of effective chemotherapeutic drugs. A series
Tullayakorn Plengsuriyakarn, Kanawut Kotawong, Juntra Karbwang, Kesara Na-Bangchang   +3 more
doaj   +1 more source

Intrahepatic Cholangiocarcinoma [PDF]

Surgical Oncology Clinics of North America, 2014
Intrahepatic cholangiocarcinoma (ICC) is a rare tumor, with an increasing incidence worldwide and an overall poor prognosis. Symptoms are usually nonspecific, contributing to an advanced tumor stage at diagnosis. The staging system for ICC has recently been updated and is based on number of lesions, vascular invasion, and lymph node involvement ...
Kimberly M, Brown, Abhishek D, Parmar, David A, Geller   +2 more
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population

Scientific Reports, 2022
The rate of cholangiocarcinoma (CCA) is increasing every year, especially in northeastern Thailand. Screening for CCA using ultrasonography (US) is the fastest technique to identify patients in early stage of CCA development.
Kavin Thinkhamrop, Narong Khuntikeo, Nittaya Chamadol, Apiporn T. Suwannatrai, Surachai Phimha, Matthew Kelly   +5 more
doaj   +1 more source