Results 41 to 50 of about 89,075 (280)

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

Nature Reviews Gastroenterology &Hepatology, 2016
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide.
J. Banales, V. Cardinale, G. Carpino, M. Marzioni, J. Andersen, P. Invernizzi, G. E. Lind, T. Folseraas, S. Forbes, L. Fouassier, A. Geier, D. Calvisi, J. Mertens, M. Trauner, A. Benedetti, L. Maroni, J. Vaquero, R. Macías, C. Raggi, M. Perugorria, E. Gaudio, K. Boberg, J. Marin, D. Alvaro   +23 more
semanticscholar   +1 more source

Cholangiocarcinoma

Surgical Clinics of North America, 1990
The diagnosis of cholangiocarcinoma can now be made with greater rapidity and accuracy. In the clinical setting of obstructive jaundice, a CT scan or sonogram may suggest cholangiocarcinoma if dilated intrahepatic ducts are seen with a nondilated extrahepatic biliary tree.
C J, Yeo, H A, Pitt, J L, Cameron
openaire   +2 more sources

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

Frontiers in Medicine, 2018
Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates.
Narong Khuntikeo, Narong Khuntikeo, Attapol Titapun, Attapol Titapun, Watcharin Loilome, Watcharin Loilome, Puangrat Yongvanit, Puangrat Yongvanit, Bandit Thinkhamrop, Bandit Thinkhamrop, Nittaya Chamadol, Nittaya Chamadol, Thidarat Boonmars, Thidarat Boonmars, Teerachai Nethanomsak, Teerachai Nethanomsak, Ross H. Andrews, Ross H. Andrews, Trevor N. Petney, Trevor N. Petney, Paiboon Sithithaworn, Paiboon Sithithaworn   +21 more
doaj   +1 more source

Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development

Molecular Cancer, 2021
The mRNA-based cancer vaccine has been considered a promising strategy and the next hotspot in cancer immunotherapy. However, its application on cholangiocarcinoma remains largely uncharacterized.
Xing Huang, Tianyu Tang, Gang Zhang, T. Liang   +3 more
semanticscholar   +1 more source

Identification of serum metabolite biomarkers and metabolic reprogramming mechanisms to predict recurrence in cholangiocarcinoma

Scientific Reports
Cholangiocarcinoma (CCA) has high recurrence rates that severely limit long-term survival. Effective tools for accurate recurrence monitoring and diagnosis remain lacking.
Piya Prajumwongs, Attapol Titapun, Vasin Thanasukarn, Apiwat Jareanrat, Natcha Khuntikeo, Nisana Namwat, Poramate Klanrit, Arporn Wangwiwatsin, Jarin Chindaprasirt, Supinda Koonmee, Prakasit Sa-Ngiamwibool, Nattha Muangritdech, Sittiruk Roytrakul, Watcharin Loilome   +13 more
doaj   +1 more source

Clinicogenomic analysis of FGFR2-rearranged cholangiocarcinoma identifies correlates of response and mechanisms of resistance to pemigatinib.

Cancer Discovery, 2020
Pemigatinib, a selective fibroblast growth factor receptor (FGFR) 1-3 inhibitor, has demonstrated antitumor activity in FIGHT-202, a phase 2 study in patients with cholangiocarcinoma harboring FGFR2 fusions/rearrangements, and has gained regulatory ...
I. Silverman, A. Hollebecque, L. Friboulet, S. Owens, R. Newton, H. Zhen, L. Féliz, C. Zecchetto, D. Melisi, T. Burn   +9 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Predicting cisplatin response in cholangiocarcinoma patients using chromosome pattern and related gene expression

Scientific Reports
Cholangiocarcinoma (CCA) is a prevalent bile duct cancer with limited treatment options. Cisplatin-based chemotherapy is a common approach, but response rates vary.
Sutheemon Techa-ay, Sasithorn Watcharadetwittaya, Raksawan Deenonpoe, Kitti Intuyod, Waleeporn Kaewlert, Anchalee Techasen, Watcharin Loilome, Poramate Klanrit, Manida Suksawat, Kwanjira Chaleekan, Sirinya Sitthirak, Malinee Thanee   +11 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Performance of Mini Parasep® SF stool concentrator kit, Kato-Katz, and formalin-ethyl acetate concentration methods for diagnosis of opisthorchiasis in Northeast Thailand

Parasites & Vectors, 2022
Background Control and elimination of the liver fluke (Opisthorchis viverrini) is a primary preventive strategy against cholangiocarcinoma in Southeast Asia.
Kulthida Y. Kopolrat, Seri Singthong, Narong Khuntikeo, Watcharin Loilome, Chanika Worasith, Chutima Homwong, Chompunoot Wangboon, Patiwat Yasaka, Chatanun Eamudomkarn, Opal Pitaksakulrat, Krisnakorn Tonkhamhak, Arunee Paeyo, Thomas Crellen, Jiraporn Sithithaworn, Paiboon Sithithaworn   +14 more
doaj   +1 more source